What is the difference between potassium oxalate and potassium EDTA anticoagulant?

 

In clinical medicine, there is a substance that can fully prevent blood coagulation, that is, anticoagulants, including heparin, EDTA salt, citrate and potassium oxalate, which are of many types and difficult to distinguish. On the surface, EDTA dipotassium and potassium oxalate belong to the same reagent type, which is somewhat similar. Many people will confuse them, but there are great differences fundamentally. Let me give you a detailed analysis.

 

1、 Different anticoagulation mechanisms

Dipotassium EDTA can be compatible with calcium in the blood and can be complexed with it, so that prothrombin cannot be converted into thrombin, so as to prevent blood coagulation. Generally, every 0.8mg EDTA can anticoagulate 1ml of blood. Although potassium oxalate and potassium EDTA can complexe calcium in the blood, it is combined to form calcium oxalate precipitation in the process of preventing blood coagulation, not by inhibiting thrombin.

 

2、 Different requirements for preparation of anticoagulant tubes

The requirements for the preparation of anticoagulant tubes by potassium EDTA and potassium oxalate are different. During the preparation of anticoagulant tubes by potassium oxalate, the temperature conditions need to be controlled at 80 ℃ for drying. If the temperature exceeds 80 ℃, potassium oxalate may decompose into potassium carbonate and carbon monoxide, thus losing the anticoagulant effect. However, when preparing anticoagulant tubes, potassium EDTA can still maintain the anticoagulant effect by drying at 100 ℃ without fear of decomposition. Therefore, its preparation conditions are easier to control, and it will be more convenient to produce compared with potassium oxalate, which is conducive to improving efficiency.

 

3、 Different addition amount

Generally, 0.2ml of 10% potassium oxalate solution is added to the vacuum tube, and then the tube is gently tapped to make the solution fully contact the tube wall. At this time, the amount of addition can make 3-5 ml of blood not coagulate, which is not applicable to the determination of potassium ion and calcium ion content. However, the added concentration of EDTA potassium is 1.4-1.6g/L blood, which is suitable for routine blood testing. Because of its influence on white blood cell count, it is not suitable for cell count testing.

 

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