Heparin is a naturally occurring glycosaminoglycan produced in the body by basophils and mast cells. It is mainly located in the granules of tissue mast cells that are closely related to the immune response. This substance was used a hundred years ago. Found. Heparin is the first anticoagulant discovered and isolated for medical use, and it is one of the oldest drugs widely used clinically.
Even now, heparin is still on the World Health Organization's standard list of essential medicines and is a safe and effective medicine required by the health care system. Because it can accelerate the speed of antithrombin inhibiting serine protease in the coagulation cascade. Heparin and the structurally related heparan sulfate are complex linear polymers composed of a mixture of chains of different lengths with variable sequences. Heparin interacts most closely with peptides that contain complementary binding sites with high positive charge density. Heparin and heparan sulfate mainly exhibit linear helical secondary structures, in which sulfonic and carboxyl groups are displayed along the polysaccharide backbone at defined intervals and in defined directions.
Heparin is similar to DNA in that both are highly charged linear polymers that behave as polyelectrolytes. Heparin is believed to act as an anticoagulant mainly by interacting with AT-III and enhancing the inhibition of AT-III-mediated coagulation factors (including thrombin and factor Xa). Heparin binds to AT-III and thrombin in the form of a ternary complex, which increases the bimolecular rate constant of thrombin inhibition by 2000 times.
Desheng Company is a manufacturer specializing in the production of blood collection tube additive products. It has been more than ten years since the establishment of the company in 2005. The main products produced and operated include: heparin lithium, heparin sodium, serum separation gel, EDTA dipotassium/tripotassium, and procoagulant We have a professional team to manage R&D and production of products such as coagulant, accelerator powder, potassium oxalate, siliconizing agent and so on. If you are interested in Desheng's products, you can enter the company's official website to contact customer service for more information, welcome your letter!