Introduction of anticoagulant and blood sample preservation solution ACD

 

With the progress and development of medicine, the appearance of additives for blood collection vessels has not only changed the traditional detection methods, but also improved the detection efficiency and promoted the detection results to be more accurate. Of course, in the whole blood testing process, there is not only one kind of blood sampling additives, including coagulant, anticoagulant, serum gel, etc. Next, we will introduce the preservation time of anticoagulant and blood sample preservation solution for blood collection.

 

Main types of anticoagulants

 

1. Sodium citrate: In the whole blood transfusion process, the anticoagulant that plays an important role is sodium citrate. It can combine with the calcium ions of the blood collected to make it lose its reaction in coagulation, and be metabolized by the body after the transfusion backlog. In addition to anticoagulation, it can also prevent hemolysis.

 

2. EDTA potassium salt: EDTA potassium salt anticoagulants are recognized as ideal anticoagulants and also widely used reagents, mainly because they contain EDTA, which is close to calcium in the blood and prevents blood from clotting at the source, so as to achieve the goal of anticoagulation.

 

3. Heparin salt: Heparin sodium and heparin lithium are widely used. Their anticoagulant effect is controlled by heparin. Previously, heparin anticoagulation was used to avoid hypocalcemia caused by sodium citrate anticoagulation, but this problem does not occur now. Heparin will be widely used in blood collection vessels. However, it should be noted that heparin anticoagulation needs to be tested within 48 hours.

 

Storage time of blood preservation solution

 

Why is blood preservation solution mentioned here? It is mainly related to sodium citrate. The blood preservation solution can be divided into two categories: ACD and CPD according to the difference in formula. Among them, ACD is composed of citric acid, glucose and phosphate. In addition to the basic anticoagulation function, it also has the role of protecting blood cells. On this basis, it can extend the storage life of red blood cells.

 

If only sodium citrate is used, the shelf life may be only about 5 days. However, if ACD solution containing sodium citrate is used, the shelf life can reach about 20 days, which not only extends the shelf life, but also effectively prevents hemolysis.

 

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