Causes of non coagulation of blood in evacuated blood collection vessels

 

To put it simply, blood coagulation means that the blood cannot flow. When the human body draws blood into the test tube and shakes the test tube, it will be found that the blood shakes with it, indicating that there is no coagulation. It is an important condition for physiological hemostasis. The essence is that fibrin in plasma needs enzymatic reaction and various coagulation factors to participate in the process of changing from soluble to insoluble.

 

At present, many medical institutions use component blood transfusion, which means that various components in the blood, such as red blood cells and platelets, are separated by centrifugation for detection. This not only improves efficiency, but also saves medical resources to a large extent. Normally, after leaving the human body, the blood will basically coagulate by itself after being put aside for more than 1 hour, but many people will find that the test tubes in the hospital are not coagulated even after being put aside for 24 hours. What is the reason?

 

1、 Self blood causes

 

Many people have insufficient white blood cells in their blood cell components, which leads to a weak mechanism of coagulation factors and will not produce coagulation. It is suggested that patients should have coagulation tests in time. For example, lack of vitamin C and K will lead to coagulation dysfunction.

 

2、 Coagulation mechanism is affected

 

In fact, it is closely related to the blood coagulation process. There are many blood components, such as red blood cells, platelets, plasma, etc. The coagulation effect is the result of the combined reaction of platelets and plasma. In particular, the coagulation factors and fibrin contained in the plasma are a key link in the whole coagulation mechanism. When the coagulation mechanism is affected by the external environment or additives, it will block the coagulation process, so even if the shelving time is extended, it will not coagulate.

 

3、 Anticoagulant is added to the test tube

 

Another situation is that anticoagulants are added to the blood collection vessels in medical institutions, so the blood will not coagulate in a short time. Common anticoagulants include heparin salt, EDTA potassium salt, etc. Heparin salt can fully combine with antithrombin, inactivate coagulation factors, and rapidly interfere with the role of thrombin, so it can fully block blood coagulation. As an important complexing substance, EDTA can tightly hold calcium ions in the blood, prevent them from reacting, and interfere with the coagulation process, so as to achieve the goal of anticoagulation. During the use of anticoagulants, it is very important to shake the blood sufficiently after blood collection to avoid the simultaneous occurrence of coagulation and non coagulation.

 

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