Heparin and EDTA salt are anticoagulants, what's the difference?

There are many kinds of anticoagulants used in current clinical medicine, but we are familiar with heparin, ethylenediaminetetraacetate dihydrate, potassium oxalate, sodium fluoride and sodium citrate. Their functions are to prevent rapid coagulation of blood in vitro. However, due to different testing items that require analysis in clinical practice, we need to carefully identify which anticoagulant to use to avoid the influence of anticoagulant itself on blood samples, To obtain accurate detection results.

Heparin anticoagulants mainly include heparin sodium and heparin potassium, which are one of the commonly used anticoagulants in the hospital laboratory. They mainly combine with antithrombin III to change its structure and activate thrombin. Antithrombin III forms a complex with thrombin, which weakens the thrombin effect. Accordingly, the process of transforming fibrinogen into fibrin is weakened, and the coagulation time is greatly prolonged. Since heparin can improve the reaction speed to a thousand times, the blood collection vessels added with heparin are generally used for emergency biochemistry. In addition, the blood samples treated with heparin anticoagulation can be used to analyze serum electrolyte or blood gas.

Ethylenediaminetetraacetate dihydrate refers to disodium ethylenediaminetetraacetate, dipotassium and tripotassium, which are currently the most used anticoagulants and belong to chelating anticoagulants, because they can prevent blood coagulation by chelating with calcium ions. It should be specially pointed out that potassium salt is more soluble than sodium salt in blood samples, so it is used more widely, and two potassium is used more widely than three potassium.

Heparin is mainly isolated from animal tissues, and the amount obtained is small; The blood samples treated with EDTA were less clots than those treated with heparin; In addition, heparin can only play a role in delaying the coagulation process and cannot prevent coagulation. The specifications of heparin sodium and heparin lithium developed by Desheng Biochemical Technology Co., Ltd. are 10g/bottle and 50g/bottle, and the specifications of potassium salt and sodium salt of ethylenediaminetetraacetic acid are 500g/bottle, both of which are certified by the ISO9001 quality system. The quality is guaranteed. For more information, please consult the official website.