Total synthetic route of  luteolin
Luteolin was synthesized from phloroglucinol with the total yield of about 34%.
Step 1: Phloroginol and 3, 4-dimethoxy-ethyl benzoylacetate were refluxed for 2 hours at 140 ~ 160℃ under vacuum (1330Pa), and diphenyl ether was added after slightly cooling. The reaction was performed at 140 ~ 160℃ under vacuum (1330Pa) for 4 ~ 5 hours to dealcoholize and dehydrate, and then filtered after cooling. 95% ethanol is added to obtain the intermediate 3',4' -dimethoxy-5, 7-dihydroxyflavone.
Step 2: 3',4' -dimethoxy-5, 7-dihydroxy-flavone was added with catalyst anhydrous pyridine, and then added with catalyst aluminum chloride at 100℃, and the two methyl groups on the 3' and 4' position were removed at 160 ~ 180℃ for 3 ~ 5 hours. The reactants were hydrolyzed in water, cooled to obtain luteolin crude, which was washed and recrystallized to obtain luteolin pure.

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