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Bitter apricot seed extract amygdalin
Release time: 2022-12-14
About Amygdalin Vitamin B17
Amygdalin is the main ingredient of bitter apricot seed extract, also known as laevomandelonitrile or laetrile, is isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds. Since the early 1950s, a modified form of almond extract amygdalin has been promoted under the names laetrile and "Vitamin B17" as a cancer cure. In reality, neither amygdalin nor any derivative such as laetrile is in any sense a vitamin.
Bitter apricot seed extract is the purified form of the compound amygdalin, which is found naturally in fruits and vegetables, particularly in the apricot pits and bitter almonds.Bitter apricot seed extract amygdalin was first isolated in 1830 and was used as an anticancer agent in Russia as early as It is believed that laetrile relieves the pain of cancer. One theory is that cancer cells contain large quantities of the enzyme beta-glucosidase.
This enzyme breaks the amygdalin down and releases cyanide, a toxic chemical that then kills cancer cells.
| Description | Amygdalin is a cyanogenic glycoside that has been found in seeds from plants of the Rosaceae family and has diverse biological activities. It induces cell cycle arrest at the G0/G1 phase, decreases cyclin A and Cdk2 levels, and inhibits cell growth in UMUC-3, RT112, and TCCSUP bladder cancer cells when used at concentrations ranging from 1.25 to 10 mg/ml. Amygdalin (3 mg/kg) reduces the number of primary microtubules and microvessels in aortic rings isolated from rats with diabetes induced by streptozotocin (Item No. 13104). In vivo, amygdalin reduces triglyceride, total cholesterol, and LDL levels and aortic sinus plaque area in an LDLR-/- mouse model of atherosclerosis. It also reduces production of TNF-α, IL-1β, and IL-6, as well as neutrophil and macrophage infiltration, in bronchoalveolar lavage fluid (BALF) in a mouse model of LPS-induced acute lung injury. |
Specification:
Almond Extract
Product Name: Almond Extract
Botanical Name: Prunus dulcis
Main components:Amygdalin
Part Used: Seed
Specification: 98% Amygdalin
CAS No:29883-15-6
Molecular Formula: C20H27NO11
Molecular Weight: 457.48
Appearance: White Fine Powder
Function:
1. Amygdalin also has anti-clotting effect.
2. Amygdalin can specifically inhibit the urea-induced elevation of blood glucose, the intensity of action and the concentration of
amygdalin in the blood.
3. Amygdalin can increase the type I collagenase activity secreted by human renal fibroblasts (KFB), inhibit the proliferation of human
renal KFB and the expression of type I collagen, and promote the apoptosis of KFB in the kidney in the optimal concentration range
and action time .
Application:
1. Applied in Medicine
2. Applied in Cosmetics
3. Applied in Dietary supplement
4. Applied in Food additive
| Amygdalin Chemical Properties |
| Melting point | 223-226 °C |
| alpha | -38.5 º (c=4, H2O) |
| Boiling point | 563.27°C (rough estimate) |
| density | 1.4474 (rough estimate) |
| refractive index | -40 ° (C=2, H2O) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | H2O: 0.1 g/mL hot, clear to very faintly turbid, colorless |
| pka | 12.69±0.70(Predicted) |
| form | Powder |
| color | White to Off-white |
| optical activity | [α]20/D 39±2°, c = 2% in H2O |
| Water Solubility | 83 g/L (25 ºC) |