Honokiol （Magnolia Bark Extract）Overview

Honokiol Source

Magnolia officinalis (Latin name: Magnolia officinalis Rehd. Et Wils.) is a deciduous tree of the genus Magnolia.
Chinese medicine magnolia officinalis refers to its dry bark and root. Magnolia officinalis, as a kind of traditional and aromatic Chinese medicine, has great pharmacological effect. In recent years, there are increasing studies on magnolia at home and abroad. The application of magnolia extract (mainly known as Magnolol and Honokiol) with new effects has been continuously explored in cosmetics field.

Product Name	CAS Number	INCI Name
Honokiol	35354-74-6	HONOKIOL
Molecular Formula	Molecular Weight	Molecular Structure
C18H18O2	266.33g/mol
Production enterprise	Specificcation	Package	Minimal Order Quantity
staherb	1-98%	1KG，25kg	1KG

Honokiol Benefits

Anti-bacterial
Honokiol has a broad anti-bacterial spectrum. Its antibacterial property is stable, and it’s not easy to be damaged by heat, acid, alkali. Some scholars have found that Honokiol has a strong inhibitory effect on streptococcus mutans. The result shows that it has good antibacterial effect on staphylococcus aureus; and its MIC is 6.25μg/mL. Therefore, Honokiol can be added into cosmetics to treat acne, and can also be used as a natural preservative of cosmetics.

Anti-acne and anti-inflammation
Honokiol has strong inhibitory effect on P.acnes and P.granulosum that can lead to acne. The MIC is 9mg/L. Furthermore, it can effectively reduce the increase of THP-1cell, IL-8 and TNF-αcaused by P.acnes. So it proves that Honokiol can treat local skin inflammation.

Anti-aging and whitening

Study has shown that Honokiol can enhance activity of antioxidant enzymes such as SOD, CAT and GSH2Px in serum and tissues of mice; and it can lower the content of MDA, a lipid peroxide in the body. Under the action of Honokiol, antioxidant capacity of human body has been improved. And excessive free radicals produced by aging body can be quickly eliminated. Thereby, further chain reaction of oxygen free radical is blocked, and per-oxidation process of tissues and cells is inhibited. Thus Honokiol can exert its anti-aging effect. Moreover, the scavenging capacity of Honokiol on free radicals is stronger than that of classic antioxidant ascorbic acid. And Honokiol can also inhibit tyrosinase activity; so it has certain whitening function, and can be used in cosmetics as skin whitening agent.

Honokiol Application
*Honokiol is widely used in cosmetics and other daily chemicals:

*Dental products (toothpaste, mouth wash) for prevention of gingivitis; recommended dosage is 0.3%. As *a natural preservative in cosmetics.
*Anti-pimple and anti-acne facial essence, lotion, cream, etc;
*As anti-aging and whitening agent in sunscreen, cleanser, mask and other skin care products.

Honokiol Safety

*Cosmetic, Toiletry & Fragrance Association (CTFA) has specified Honokiol as a cosmetics ingredient.

*Honokiol is listed on The International Catalogue of Chinese Cosmetic Raw Materials Standards in 2010 issued by CAFFCI and On the Announcement of Name List of Cosmetics Raw Material published by CFDA in 2014. No reports show its insecurity.