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Cynarin
Release time: 2022-11-25
|
Product Name: |
Cynarin |
|
Synonyms: |
1,5-DICAFFEOYLQUINIC ACID;1,3-DICAFFEOYLQUINIC ACID;Dicaffeoylquinic Acid, 1,3-;Cynarin, 98%, from Lonicera japonica;(1R,3R,4S,5R)-1,3-Bis((3-(3,4-dihydroxyphenyl)acryloyl)oxy)-4,5-dihydroxycyclohexanecarboxylic acid;CYNARIN(ECHINACEA);CYNARIN(ARTICHOKE);CYNARIN |
|
CAS: |
30964-13-7 |
|
MF: |
C25H24O12 |
|
MW: |
516.45 |
1,3-Dicaffeoylquinic acid is a polyphenol that has been found in C. scolymus. It decreases the expression and protein levels of inducible nitric oxide synthase (iNOS) when used at a concentration of 10 μM in human coronary artery smooth muscle cells (HCASMCs) treated with a cytokine mixture. 1,3-Dicaffeoylquinic acid decreases protein levels of tyrosinase and microphthalmia-associated transcription factor (MITF) in B16F1 murine melanocytes. It inhibits melanogenesis in B16F1 cells and decreases tyrosinase activity in cell lysates when used at a concentration of 25 μM. 1,3-Dicaffeoylquinic acid (20 and 40 μM) reduces triglyceride levels in sodium oleate-induced hyperlipidemic HepG2 cells compared to hyperlipidemic control cells.
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