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Changsha Staherb Natural Ingredients Co., Ltd.,

Changsha Staherb Natural Ingredients Co., Ltd.,

Main products: magnolol,Dihydromyricetin,Macleaya Cordata Extract,corosolic acid,Amygdalin

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Honokiol is a natural biphenyl neolignan from magnolia extract

Release time: 2022-11-23

Product Name: Honokiol
Synonyms: 5,3'-DIALLYL-BIPHENYL-2,4'-DIOL;HONOKIOL;1’-Biphenyl]-2,4’-diol,3’,5-di-2-propenyl-[1;HONEYSUCKLEFLOWEREXTRACT;Honokiol,(S);3',5-Diallyl-2,4'-biphenyldiol;3',5-Diallyl[1,1'-biphenyl]-2,4'-diol;3,3'-DIALLYL-4,6'-DIHYDROXYBIPHENYL
CAS: 35354-74-6
MF: C18H18O2
MW: 266.33
EINECS: 609-119-8

 

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Uses Honokiol has been used:
  • to study its effects on plasmid hSirt3102-399 deacetylation activity
  • as an antioxidant to study its cytoprotective role in human ovarian cancer cells (SKOV-3) and Chinese hamster ovary cells (CHOK1)
  • to explore its effects on oxidative stress and mitochondrial dysfunction via a sirt3-dependent manner
  • for intracerebroventricular (ICV) cannulation
Uses Honokiol is a small-molecule polyphenol isolated from the genus Magnolia. Recent studies show that Honokiol displays antiangiogenic, antiinflammatory, and antitumor properties in preclinical models, w ithout appreciable toxicity. Honokiol has been shown to inhibit the bone metastatic growth of human prostate cancer cells.
Indications These compounds are recorded in the British Pharmacopoeia (2017) and European Pharmacopoeia (8.7th ed.). They are mainly used as antibacterial and antifungal agents.
General Description Honokiol exhibits analgesic, antithrombotic, antispasmodic, antidepressant, antimicrobial and neuroprotective effects. It regulates gamma-aminobutyric acid (GABA) A receptors. Honokiol is associated with an increased risk of bleeding. It prevents platelet aggregation, protects myocardium from ischemic damage and inhibits ventricular arrhythmia.
Biochem/physiol Actions Honokiol is a natural biphenyl neolignan from magnolia extract. It is antiangiogenic, antitumor, and anxiolytic.
Pharmacology Magnolol and honokiol have the pharmacological effects of prolonging central muscle relaxation, inhibition of the central nervous, anti-inflammatory, antibacterial, antimicrobial, antiulcer, antioxidant, antitumor, hormone regulation, and antidiabetes .