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Luteolin is a naturally occurring flavonoid found in a variety of plants, including broccoli, pepper, thyme, and celery. Because it inhibits the activation of mast cells and microglia and reduces the release of histamine, serotonin, glutamate, and proinflammatory factors, luteolin has multiple benefits, such as antioxidant, anti-inflammatory, neuroprotective, and improved attention and social skills in children with autism.
Although flavonoids are generally considered safe, some side effects have occurred, such as allergic reactions in individuals lacking G6PD who take flavonoids derived from peanut shells and broad beans. Therefore, flavonoids are best not taken with other natural polyphenols or with drugs that affect liver metabolism.