The corosolic acid (CA), another name plant insulin, is a pentacyclic triterpenoid source from plants such as Lagerstroemia speciosa. It can anti-diabetic, anti-inflammatory and anti-tumor effects. The corosolic acid structural analogs ursolic acid (UA), oleanolic acid (OA), maslinic acid (MA), asiatic acid (AA) and betulinic acid (BA) display similar individual pharmacological activities to those of The corosolic acidCA.

The corosolic acid (CA) structural analogs are pentacyclic triterpenes extracted from banaba leaf and they have low solubilities in water due to their rigid scaffold and hydrophobic properties. By introduction of water-soluble groups such as sugar or amino groups could increase the solubility of The corosolic acid (CA)structural analogs. Their biological activities and underlying mechanism of action are reviewed and compared.

The corosolic acid (CA) structural analogs UA, OA, MA, AA and BA are demonstrated The corosolic acid (CA) can lowering blood sugar, anti-inflammation and anti-tumor. Their oral absorption and bioavailability can be improved through structural modification and formulation design. The corosolic acid (CA) structural analogs are promising natural product-based lead compounds for further development and mechanistic studies.

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