Magnolol and Honokiol Skin Benefits

Anti-Inflammation and Anti-Acne

The P. acnes inhibitory test was conducted on 22 active ingredients with anti-inflammatory effects. The results showed that magnolol has a good inhibitory effect on P. acnes, which is better than metronidazole. Moreover, studies have confirmed that magnolol can inhibit inflammatory enzymes, cytokine production, NF-κB, MAPKs activation and leukocyte activation, showing certain anti-inflammatory properties.Honokiol has a strong inhibitory effect on P.acnes (Propionibacterium acnes) and P.granulosum (Propionibacterium granules) that cause acne. The Minimum Inhibitory Concentration is 9 mg/L. And it can effectively reduce the increase of IL-8 and TNF-α in THP-1 cells caused by P.acnes, which indicates that honokiol can be used to treat skin inflammation.

Anti-Aging

Using fluorescence spectrophotometry, it is proved that magnolol and honokiol are the main components of magnolia in scavenging hydroxyl radicals and hydrogen peroxide, and the mass concentration of scavenging hydroxyl radicals is 0.081 mg/L and 0.091 mg/L respectively. Studies have found that magnolol can significantly inhibit the increase in the expression of MMP-1, MMP-9, and MMP-13 in the skin of mice caused by UVB irradiation, so magnolol has anti-photoaging effect. Also, magnolol and honokiol can be used as a sun protection agent to prevent skin irritation caused by UV.

Good solubility is a key point for cosmetic formula. Magnolol and honokiol both have great solubility in butanediol. Changsha Staherb Natural Ingredients Co., Ltd. produce 98% magnolol and 98% honokiol, they are high-purity active ingredients with off-white color. Magnolol and honokiol benefit skin a lot, and they are mainly applied in anti-inflammation and anti-acne cosmetics.