What is Polydatin ?

Giant knotweed extract polydatin is the glycoside of resveratrol originally isolated from the Chinese herb Polygonum cuspidatum. The polydatin has been shown to inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. Myocardial cell, white blood cell, vascular smooth muscle cell, and endothelial cell studies report that polydatin can inhibit ICAM-1 expression, elevate Ca2+, weaken white blood cell-endothelial cell adhesion, and activate KATP channels.

Polydatin specifications:

English name: Polydatin
Latin Name: Polygonum cuspidatum
Specification: 98% Polydatin
Use Part : Herb
Appearance: white fine powder
Mesh size: 100% pass 80 Mesh
Test Method: HPLC

Function:

1. Antibacterial, antithrombotic, antiinflammatory and antianaphylaxis

2. Preventing cancer, especially breast cancer, prostate cancer, endometrial cancer and ovary cancer, due to its estrogen role.

3. Antioxidation, delaying aging, preventing osteoporosis, acne(whelk) and dementia in the elderly.

4. Lowering cholesterin and the blood viscosity, reducing the risk of arteriosclerosis, cardio-cerebrovascular disease and heart disease

5. Owning good efficacy for treatment of AIDS

Staherb natural ingredients-----professional manufacturer of magnolia bark extract,vine tea extract,myricetin,honeysuckle flower extract,eucommia leaf extract,rosemary extract,macleaya cordata extract,banaba leaf extract.

 Remarks:

The above information about banaba leaf extract is from the Internet and literature for reference only.

Changsha staherb natrual ingredients co.,ltd is a professional standardized plant extract production enterprise,the products are only for enterprise customers.

Refereces:

1.Peng, W., Qin, R. X., Li, X. L., & Zhou, H. (2013). Botany, phytochemistry, pharmacology, and potential application of Polygonum cuspidatum Sieb.et Zucc.: a review. Journal of Ethnopharmacology, 148, 729–745.

2.Wang, X. M., Song, R., Chen, Y. Y., Zhao, M., & Zhao, K. S. (2013). Polydatin-a new mitochondria protector for acute severe hemorrhagic shock treatment. Expert Opinion on Investigational Drugs, 22, 169–179.

3.Hao, J., Chen, C., Huang, K., Huang, J., Li, J., Liu, P., & Huang, H. (2014). Polydatin improves glucose and lipid metabolism in experimental diabetes through activating the Akt signaling pathway. European Journal of Pharmacology, 745, 152–165.

4.Cook, J., Addicks, W., & Wu, Y. H. (2008). Application of the biopharmaceutical classification system in clinical drug development—an industrial view. The AAPS Journal, 10, 306–310.

5.Pouton, C. W., & Porter, C. J. H. (2008). Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies. Advanced Drug Delivery Reviews, 60, 625–637.

6.Viskupicova, J., Danihelova, M., Ondrejovic, M., Liptaj, T., & Sturdik, E. (2010). Lipophilic rutin derivatives for antioxidant protection of oil-based foods. Food Chemistry, 123, 45–50.

7.Liu, L. Y., Jin, C., & Zhang, Y. (2014). Lipophilic phenolic compounds (Lipo-PCs): emerging antioxidants applied in lipid systems. RSC Advances, 4, 2879–2891. 

8.Céliz, G., Martearena, M. R., Scaroni, E., & Daz, M. (2012). Kinetic study of the alkyl flavonoid ester prunin 6″-O-laurate synthesis in acetone catalysed by immobilised Candida antarctica lipase B. Biochemical Engineering Journal, 69, 69–74.

9.González-Sabín, J., Morán-Ramallal, R., & Rebolledo, F. (2011). Regioselective enzymatic acylation of complex natural products: expanding molecular diversity. Chemical Society Reviews, 40, 5321–5335.

10.Katsoura, M. H., Polydera, A. C., Tsironis, L., Tselepis, A. D., & Stamatis, H. (2006). Use of ionic liquids as media for the biocatalytic preparation of flavonoid derivatives with antioxidant potency. Journal of Biotechnology, 123, 491–503.

11.Céliz, G., Audisio, M. C., & Daz, M. (2010). Antimicrobial properties of prunin, a citric flavanone glucoside, and its prunin 6″-O-auroyl ester. Journal of Applied Microbiology, 109, 1450–1457.

12.Salamone, S., Guerreiro, C., Cambon, E., André, I., Remaud-Siméon, M., & Mulard, L. A. (2015). Programmed chemo-enzymatic synthesis of the oligosaccharide component of a carbohydrate-based antibacterial vaccine candidate. Chemical Communications, 51, 2581–2584.

13.Iglesias, L. E., Lewkowicz, E. S., Medici, R., Bianchi, P., & Iribarren, A. M. (2015). Biocatalytic approaches applied to the synthesis of nucleoside prodrugs. Biotechnology Advances, 33, 412–434.

14.Liu, J., & Linhardt, R. J. (2014). Chemoenzymatic synthesis of heparan sulfate and heparin. Natural Product Reports, 31, 1676–1685.

15.Clouthier, C. M., & Pelletier, J. N. (2012). Expanding the organic toolbox: a guide to integrating biocatalysis in synthesis. Chemical Society Reviews, 41, 1585–1605.

16.Gumel, A. M., Annuar, M. S. M., Heidelberg, T., & Chisti, Y. (2011). Lipase mediated synthesis of sugar fatty acid esters. Process Biochemistry, 46, 2079–2090.

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