Alpha Arbutin is the active substance originated from natural plant which can whiten and lighten skin. Alpha Arbutin Powder can infiltrate into the skin quickly without affecting the concentration of cell multiplication and effectively prevent activity of tyrosinase in the skin and the forming of melanin. By combined arbutin with tyrosinase, decomposition and drainage of melanin are accelerated, splash and fleck can be got ride of and no side effects are caused.Arbutin Powder is one of the safest and most efficient whitening materials that are popular at present. Alpha Arbutin is also the most competitive whitening activity in the 21st century.

Alpha-arbutin is similar to β-arbutin, which inhibits the production and deposition of melanin and eliminates spots and freckles. Studies have shown that α-arbutin can inhibit the activity of tyrosinase at a lower concentration, and its inhibition of tyrosinase is better than that of β arbutin.

Product name:Alpha arbutin

Form:Powder

Cas No.:84380-01-8

Molecular Formula:C12H16O7

Molecular Weight:272.25

Appearance:White crystalline powder

Test Method:HPLC

Specification:99%

Alpha arbutin main function:

1. Cosmetic Field Function.
(1) Alpha arbutin powder can protect the skin against damage caused by free radicals.have the function of anti-aging

(2) Alpha arbutin powder is a skin whitening agent

(3) Alpha arbutin powder inhibits the formation of melanin pigment by inhibiting Tyrosinase activity. 

Staherb natural ingredients-----professional manufacturer of magnolia bark extract,vine tea extract,myricetin,honeysuckle flower extract,eucommia leaf extract,rosemary extract,macleaya cordata extract,banaba leaf extract.

Remarks:
The above information about alpha arbutin is from the Internet and literature for reference only.

Changsha staherb natrual ingredients co.,ltd is a professional standardized plant extract production enterprise,the products are only for enterprise customers.

References：

1.Saeedi M, Eslamifar M, Khezri K. Kojic acid applications in cosmetic and pharmaceutical preparations. Biomedicine & Pharmacotherapy. 2019;110:582–93.

2.Desmedt B, Courselle P, De Beer JO, Rogiers V, Grosber M, Deconinck E, et al. Overview of skin whitening agents with an insight into the illegal cosmetic market in Europe. J Eur Acad Dermatol Venereol. 2016;30(6):943–50. 

3.Couteau C, Coiffard L. Overview of skin whitening agents: drugs and cosmetic products. Cosmetics. 2016;3(3). 

4.Migas P, Krauze-Baranowska M. The significance of arbutin and its derivatives in therapy and cosmetics. Phytochem Lett. 2015;13:35–40.

5.Sccs, Degen GH. Opinion of the Scientific Committee on Consumer safety (SCCS)—opinion on the safety of the use of α-arbutin in cosmetic products. Regul Toxicol Pharmacol. 2016;74:75–6. 

6.Won J, Park J. Improvement of arbutin trans-epidermal delivery using radiofrequency microporation. 2014.

7.Alkilani AZ, McCrudden MT, Donnelly RF. Transdermal drug delivery: innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum. Pharmaceutics. 2015;7(4):438–70. 

8.Mahato R. Chapter 13—microneedles in drug delivery. In: Mitra AK, Cholkar K, Mandal A, editors. Emerging nanotechnologies for diagnostics, drug delivery and medical devices. Boston: Elsevier; 2017. p. 331–53.

9.Pamornpathomkul B, Ngawhirunpat T, Tekko IA, Vora L, McCarthy HO, Donnelly RF. Dissolving polymeric microneedle arrays for enhanced site-specific acyclovir delivery. Eur J Pharm Sci. 2018;121:200–9.

10.Simon GA, Maibach HI. The pig as an experimental animal model of percutaneous permeation in man: qualitative and quantitative observations—an overview. Skin Pharmacol Appl Ski Physiol. 2000;13(5):229–34.

11.Touitou E, Meidan VM, Horwitz E. Methods for quantitative determination of drug localized in the skin. J Control Release. 1998;56(1–3):7–21.

12.Cilurzo F, Minghetti P, Sinico C. Newborn pig skin as model membrane in in vitro drug permeation studies: a technical note. AAPS PharmSciTech. 2007;8(4):E94-E.  

13.Davies DJ, Ward RJ, Heylings JR. Multi-species assessment of electrical resistance as a skin integrity marker for in vitro percutaneous absorption studies. Toxicol In Vitro. 2004;18(3):351–8. 

14.El-Say KM. Maximizing the encapsulation efficiency and the bioavailability of controlled-release cetirizine microspheres using Draper-Lin small composite design. Drug Des Dev Ther. 2016;10:825–39. 

15.Machekposhti SA, Soltani M, Najafizadeh P, Ebrahimi SA, Chen P. Biocompatible polymer microneedle for topical/dermal delivery of tranexamic acid. J Controlled Release. 2017;261:87–92.

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