Sialic acids refer to a family of neuraminic acids which contain nine-carbon acidic amino monosaccharides. It was originally isolated from the mucin of the submandibular gland, hence the name.The most important member of the sialic acid is N-acetylneuraminic acid (Neus Ac or NANA) occuring most abundantly in glycoproteins and glycolipids. Among all types of sialic acids, only N-acetylneuraminic acid can be found in human tissues Therefore, sialic acid, to human beings, refers to N-acetylneuraminic acid. The yield of SA through microbial fermentation production. After bacteria and liquor separation, ultrafiltration and concentration, impurity removing (protein, soluble salt), polysialic acid purification polysialic acid hydrolysis purification, both of polysialic acid and N-acetylneuraminic acid reached a purity of more than 99% after purification detected by HPLC

Product Name:Sialic acid

Other Name: N-Acetylneuraminic Acid, Neu5Ac, NANA Powder

CAS No.:131-48-6

Purity:98% min

Molecular Formular:309.2699

Appearance:Whiter powder

Sialic acid application:

1.Sialic acid for anti-inflammation;
2.Sialic acid for enhancing human immunity;
3.Sialic acid is known as mental development of "brain gold";
4.Sialic acid used for cosmetics, food, health supplements;
5.Sialic acid adding infant milk powder can increase babys’ intelligence and memory

Sialic acid main function:

1.Sialic acid for anti-virus function.
2.Sialic acid for anti-cancer function.
3.Sialic acid for anti-inflammation function.
4.Sialic acid for defensive function against bacteriological infectiong.
5.Sialic acid for controlling ability of immune system.
6.Sialic acid for restraining ability against pigmentation.
7.Sialic acid for signal transformation in nerve cells.
8.Sialic acid for play a key role in brain development and learning.
9.Sialic acid for as precursor for the manufacture of many pharmaceutical drugs.

 
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Remarks:
The above information about sialic acid is from the Internet and literature for reference only.

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Reference:

1.Aula N, Salomaki P, Timonen R, Verheijen F, Mancini G, Mansson JE, Aula P, Peltonen L (2000) The spectrum of SLC17A5-gene mutations resulting in free sialic acid-storage diseases indicates some genotype-phenotype correlation. Am J Hum Genet 67:832–840
2.Aula P, Autio S, Raivio KO, Rapola J, Thoden CJ, Koskela SL, Yamashina I (1979) “Salla disease”: a new lysosomal storage disorder. Arch Neurol 36:88–94
3.Aula P, Gahl WA (2001) Disorders of free sialic acid storage. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The Metabolic and Molecular Bases of Inherited Disease. New York, McGraw Hill, pp 5109–5120
4.Cardo PP, Lombardo C, Gatti R (1985) A simple detection of sialic acid storage disorders by urinary ‘free’ and ‘total’ sialic acid determinations. Clin Chim Acta 150:129–135
5.Denny PC, Denny PA, Allerton SE (1983) Determination of sialic acid using 2-thiobarbituric acid in the absence of hazardous sodium arsenite. Clin Chim Acta 131:333–336
6.Froissart R, Cheillan D, Bouvier R, Tourret S, Bonnet V, Piraud M, Maire I (2005) Clinical, morphological, and molecular aspects of sialic acid storage disease manifesting in utero. J Med Genet 42:829–836
7.Galjaard H (1980) Genetic Metabolic Diseases. Elsevier/North-Holland Biomedical, Amsterdam
8.Grosso S, Berardi R, Farnetani MA, Margollicci M, Mancini MG, Morgese G, Balestri P (2001) Multiple neuroendocrine disorder in Salla disease. J Child Neurol 16:775–777
9.Ito M, Ikeda K, Suzuki Y, Tanaka K, Saito M (2002) An improved fluorometric high-performance liquid chromatography method for sialic acid determination: an internal standard method and its application to sialic acid analysis of human apolipoprotein E. Anal Biochem 300:260–266
10.Krasnewich DM, Tietze F, Krause W, Pretzlaff R, Wenger DA, Diwadkar V, Gahl WA (1993) Clinical and biochemical studies in an American child with sialuria. Biochem Med Metab Biol 49:90–96
11.Mancini GM, Beerens CE, Aula PP, Verheijen FW (1991) Sialic acid storage diseases. A multiple lysosomal transport defect for acidic monosaccharides. J Clin Invest 87:1329–1335
12.Mancini GM, Hu P, Verheijen FW, van Diggelen OP, Janse HC, Kleijer WJ, Beemer FA, Jennekens FG (1992) Salla disease variant in a Dutch patient. Potential value of polymorphonuclear leucocytes for heterozygote detection. Eur J Pediatr 151:590–595
13.Powell LD, Hart GW (1986) Quantitation of picomole levels of N-acetyl- and N-glycolylneuraminic acids by a HPLC-adaptation of the thiobarbituric acid assay. Anal Biochem 157:179–185
14.Roboz J, Suttajit M, Bekesi JG (1981) Elimination of 2-deoxyribose interference in the thiobarbituric acid determination of N-acetylneuraminic acid in tumor cells by pH-dependent extraction with cyclohexanone. Anal Biochem 110:380–388
15.Seppala R, Lehto VP, Gahl WA (1999) Mutations in the human UDP-N-acetylglucosamine 2-epimerase gene define the disease sialuria and the allosteric site of the enzyme. Am J Hum Genet 64:1563–1569

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