About Angelica herb.

Angelica is an aromatic herb that grows in China, Korea, and Japan. The reputation of Angelica is second only to Ginseng and is considered the ultimate, all purpose woman''s  tonic herb. Angelica is used for almost every gynecological complaint from regulating the menstrual cycle to 

treating menopausal symptoms caused by hormonal changes.Angelica is a good remedy for colds, coughs, pleurisy, wind, colic, rheumatism and diseases of the urinary organs, and it is generally used as a stimulating expectorant, combined with other expectorants the action of which is 

facilitated, and to a large extent diffused, through the whole of the pulmonary region. 

It is also a useful agent for feverish conditions,acting as a diaphoretic.The dried root of Angelica sinensis is commonly known as Chinese angelica and is widely used in Chinese traditional medicine for gynecological ailments, fatigue, mild anemia and high blood pressure. 

Product Name: Angelica Extract/Angelica Root Extract

Part used: Root

Appearance: Brown fine powder

Specification:  Ligustilides1%-3% 

Test Method: HPLC

Color: Brown fine powder

Application of Angelica Extract

1.Chinese Angelica Sinensis Extract Powder are applied in pharmaceutical field, Salvianolic Acid Bis mainly used as raw material for clearing heat, anti-inflammation, detumescence and increasing coronary flow.

2.Chinese Angelica Sinensis Extract Powder are applied in food additives, it owns the effect of antifatigue, anti-aging and nourishing brain.

3.Chinese Angelica Sinensis Extract Powder are applied in cosmetics field, it owns the effect of whitening, anti-aging,anti-wrinkle,anti-

oxidant, activating skin Cells, making skin more tender and firm.

Staherb natural ingredients-----professional manufacturer of magnolia bark extract,vine tea extract,myricetin,honeysuckle flower extract,eucommia leaf extract,rosemary extract,macleaya cordata extract,banaba leaf extract.

Remarks:

The above information about angelica extract is from the Internet and literature for reference only.

Changsha staherb natrual ingredients co.,ltd is a professional standardized plant extract production enterprise,the products are only for enterprise customers.

References:

1.Yang C, Niu S, Lifeng Y: The aqueous extract of Angelica sinensis, a popular Chinese herb, inhibits wear debris-Induced Inflammatory osteolysis in mice. J Surg Res. 2012, 176: 476-483. 10.1016/j.jss.2011.08.011.

2.Wang H, Li W, Li J: The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis. J Nutr. 2006, 136: 360-

3.Kim K, Kim JH, Lee J, Jin HM, Lee SH, Fisher DE: Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine mediated osteoclastogenesis. J Biol Chem. 2005, 280: 35209-35216. 10.1074/jbc.M505815200.

4.Matsumoto M, Sudo T, Saito T, Osada H, Tsujimoto M: Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL). J Biol Chem. 2000, 275: 31155-31161. 10.1074/jbc.M001229200.

5.Takayanagi H: Osteoimmunology. Nat Rev Immunol. 2007, 7: 292-304. 10.1038/nri2062. 

6.Iotsova V, Caamano J, Loy J, Yang Y, Lewin A, Bravo R: Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nat Med. 1997, 3: 1285-1289. 10.1038/nm1197-1285.

7.Hayden MS, Ghosh S: Signaling to NF-κB. Genes Dev. 2004, 18: 2124-2195.

8.Crotti TN, Flannery M, Walsh NC, Fleming JD, Goldring SR, McHugh KP: NFATc1 regulation of the human beta 3 integrin promoter in osteoclast differentiation. Gene. 2006, 372: 92-102.

9.Kim Y, Sato K, Asagiri M, Morita I, Soma K, Takayanagi H: Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis. J Biol Chem. 2005, 280: 32905-32913. 10.1074/

10.Matsumoto M, Koqawa M, Wada S, Takayangi H, Tsujimoto M, Katayama S: Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1. J Biol Chem. 2004, 279: 45969-45979. 10.1074/jbc.M408795200.

11.Ikeda F, Nishimura R, Matsubara T, Tanaka S, Inoue J, Reddy SV: Criticalroles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. J Clin Invest. 2004, 114: 475-484. 10.1172/JCI200419657.

12.Wagner EF, Eferl R: Fos/AP-1 proteins in bone and the immune system. Immunol Rev. 2005, 208: 126-140. 10.1111/j.0105-2896.2005.00332.x.

13.Mohamed S: Interleukin-10 inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos and c-Jun in RAW264.7 cells and mouse bone marrow cells. Bone. 2007, 41: 592-602. 10.1016/j.bone.2007.05.016.

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