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Journal of Medicinal Chemistry

IF:6.79 CiteScore:4 Articles:804

The Journal of Medicinal Chemistry is a prestigious biweekly peer-reviewed publication that focuses on the multifaceted field of medicinal chemistry. Since its inception in 1959 as the Journal of Medicinal and Pharmaceutical Chemistry, it has evolved to become a cornerstone in the dissemination of research findings related to the design, synthesis, and development of therapeutic agents. The Journal of Medicinal Chemistry is recognized for its significant impact in the scientific community, as evidenced by its 2022 impact factor of 7.3. This metric reflects the journal's influence and the importance of its content in shaping the future of drug discovery and development. The journal serves as a vital resource for chemists, pharmacologists, and other researchers interested in the molecular mechanisms of drug action and the optimization of therapeutic compounds.

Discovery of a Novel Non-invasive AR PROTAC Degrader for the Topical Treatment of Androgenetic Alopecia

Published: 6 December 2024 DOI: 10.1021/acs.jmedchem.4c02226
Xinfei Mao, Weitong Hu, Mingfei Wu, Yuyuan Jin, Jingyi Zhao, Yihua Xu, Bizhi Li, Wentao Wang, Yiquan Wu, Jingyu Zhang, Ao Pang, Yuheng Jin, Tianyuan Zhang, Wenhai Huang, Jinxin Che, Jianqing Gao, Xiaowu Dong

An Activatable Heavy-Atom-Free Upconversion Photosensitizer for Targeted Imaging and Treatment of Tumors

Published: 5 December 2024 DOI: 10.1021/acs.jmedchem.4c02679
Chao Zhao, Wanlu Sun, Yanyan Zhu, Xiaoyan Huang, Ye Sun, Hai-Yan Wang, Yi Pan, Yi Liu

End-to-End Automated Synthesis of C(sp3)-Enriched Drug-like Molecules via Negishi Coupling and Novel, Automated Liquid–Liquid Extraction

Published: 15 December 2022 DOI: 10.1021/acs.jmedchem.2c01646
Irini Abdiaj*, Santiago Ca?ellas, Alejandro Dieguez, Maria Lourdes Linares, Brenda Pijper, Alberto Fontana, Raquel Rodriguez, Andres Trabanco, Eduardo Palao and Jesus Alcázar*,

Amantadine in the treatment of Parkinson's disease and other movement disorders.

Published: 1 December 2021 DOI: 10.1016/S1474-4422(21)00249-0
Olivier Rascol, Margherita Fabbri, Werner Poewe

Neopentyl Glycol as a Scaffold to Provide Radiohalogenated Theranostic Pairs of High In Vivo Stability

Published: 28 October 2021 DOI: 10.1021/acs.jmedchem.1c01147
Hiroyuki Suzuki*, Yuta Kaizuka, Maho Tatsuta, Hiroshi Tanaka, Nana Washiya, Yoshifumi Shirakami, Kazuhiro Ooe, Atsushi Toyoshima, Tadashi Watabe, Takahiro Teramoto, Ichiro Sasaki, Shigeki Watanabe, Noriko S. Ishioka, Jun Hatazawa, Tomoya Uehara, Yasushi Arano

Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein–Protein Interaction

Published: 22 June 2019 DOI: 10.1021/acs.jmedchem.9b00021
Angelo Aguilar, Ke Zheng, Tianfeng Xu, Shilin Xu, Liyue Huang, Ester Fernandez-Salas, Liu Liu, Denzil Bernard, Kaitlin P. Harvey, Caroline Foster, Donna McEachern, Jeanne Stuckey, Krishnapriya Chinnaswamy, James Delproposto, Jeff W. Kampf, Shaomeng Wang*

Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor

Published: 26 September 2017 DOI: 10.1021/acs.jmedchem.7b00746
Keith F. McDaniel*, Le Wang, Todd Soltwedel, Steven D. Fidanze, Lisa A. Hasvold, Dachun Liu, Robert A. Mantei, John K. Pratt, George S. Sheppard, Mai H. Bui, Emily J. Faivre, Xiaoli Huang, Leiming Li, Xiaoyu Lin, Rongqi Wang, Scott E. Warder, Denise Wilcox, Daniel H. Albert, Terrance J. Magoc, Ganesh Rajaraman, Chang H. Park, Charles W. Hutchins, Jianwei J. Shen, Rohinton P. Edalji, Chaohong C. Sun, Ruth Martin, Wenqing Gao, Shekman Wong, Guowei Fang, Steven W. Elmore, Yu Shen, Warren M. Kati

Structure–Activity Relationship (SAR) Optimization of 6-(Indol-2-yl)pyridine-3-sulfonamides: Identification of Potent, Selective, and Orally Bioavailable Small Molecules Targeting Hepatitis C (HCV) NS4B

Published: 22 November 2013 DOI: 10.1021/jm401621g
Nanjing Zhang, Xiaoyan Zhang, Jin Zhu, Anthony Turpoff, Guangming Chen, Christie Morrill, Song Huang, William Lennox, Ramesh Kakarla, Ronggang Liu, Chunshi Li, Hongyu Ren, Neil Almstead, Srikanth Venkatraman, F. George Njoroge, Zhengxian Gu, Valerie Clausen, Jason Graci, Stephen P. Jung, Yingcong Zheng, Joseph M. Colacino, Fred Lahser, Josephine Sheedy, Anna Mollin, Marla Weetall, Amin Nomeir, Gary M. Karp

New Bis-thiazolium Analogues as Potential Antimalarial Agents: Design, Synthesis, and Biological Evaluation

Published: 4 January 2013 DOI: 10.1021/jm3014585
Sergio A. Caldarelli, Siham El Fangour, Sharon Wein, Christophe Tran van Ba, Christian Périgaud, Alain Pellet, Henri J. Vial, Suzanne Peyrottes*

Rapid Discovery of Highly Potent and Selective Inhibitors of Histone Deacetylase 8 Using Click Chemistry to Generate Candidate Libraries

Published: 1 November 2012 DOI: 10.1021/jm300837y
Takayoshi Suzuki*, Yosuke Ota, Masaki Ri, Masashige Bando, Aogu Gotoh, Yukihiro Itoh, Hiroki Tsumoto, Prima R. Tatum, Tamio Mizukami, Hidehiko Nakagawa, Shinsuke Iida, Ryuzo Ueda, Katsuhiko Shirahige, Naoki Miyata*

Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of σ1 Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)

Published: 12 July 2012 DOI: 10.1021/jm3007323
José Luis Díaz*, Rosa Cuberes, Joana Berrocal, Montserrat Contijoch, Ute Christmann, Ariadna Fernández, Adriana Port, J?rg Holenz, Helmut Buschmann, Christian Laggner, Maria Teresa Serafini, Javier Burgue?o, Daniel Zamanillo, Manuel Merlos, José Miguel Vela, Carmen Almansa

Mechanism of Photoinduced Decomposition of Ketoprofen

Published: 21 March 2007 DOI: 10.1021/jm060697k
Klefah A. K. Musa, Jon M. Matxain, Leif A. Eriksson

Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA?Enzyme?Inhibitor Complex As Determined by X-ray Crystallographic Analysis

Published: 23 June 2005 DOI: 10.1021/jm050076b
Alexandra Ioanoviciu, Smitha Antony, Yves Pommier, Bart L. Staker, Lance Stewart, Mark Cushman