天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook >> journal list >> International Journal of Molecular Sciences >>article
International Journal of Molecular Sciences

International Journal of Molecular Sciences

IF: 5.59
Download PDF

Anti-Inflammatory Activities of an Anti-Histamine Drug, Loratadine, by Suppressing TAK1 in AP-1 Pathway

Published:1 April 2022 DOI: 10.3390/ijms23073986
Jiwon Jang,?Stephanie Triseptya Hunto,?Ji Won Kim,?Hwaryeong Lee,?H. Kim,?J. Cho

Abstract

Loratadine is an anti-histamine routinely used for treating allergies. However, recent findings have shown that Loratadine may also have anti-inflammatory functions, while their exact mechanisms have not yet been fully uncovered. In this paper, we investigated whether Loratadine can be utilized as an anti-inflammatory drug through a series of in vitro and in vivo experiments using a murine macrophage cell line and an acute gastritis mouse model. Loratadine was found to dramatically reduce the expression of pro-inflammatory genes, including MMP1, MMP3, and MMP9, and inhibit AP-1 transcriptional activation, as demonstrated by the luciferase assay. Therefore, we decided to further explore its role in the AP-1 signaling pathway. The expression of c-Jun and c-Fos, AP-1 subunits, was repressed by Loratadine and, correspondingly, the expression of p-JNK, p-MKK7, and p-TAK1 was also inhibited. In addition, Loratadine was able to reduce gastric bleeding in acute gastritis-induced mice; Western blotting using the stomach samples showed reduced p-c-Fos protein levels. Loratadine was shown to effectively suppress inflammation by specifically targeting TAK1 and suppressing consequent AP-1 signaling pathway activation and inflammatory cytokine production.

Substances (9)

Related products

Similar articles

IF:4.9

Pharmacology and clinical efficacy of desloratadine as an anti-allergic and anti-inflammatory drug

Expert opinion on investigational drugs D. Agrawal,etc Published: 1 March 2001
IF:6.9

Assessment of the anti-angiogenic, anti-inflammatory and antinociceptive properties of ethyl vanillin

Archives of Pharmacal Research Hyun-Joo Jung, Yun Seon Song,etc Published: 2 May 2010
IF:0

Brain histamine H1 receptor occupancy measured by PET after oral administration of desloratadine and loratadine

Proceedings for Annual Meeting of The Japanese Pharmacological Society Tadaho Nakamura,?K. Hiraoka,etc Published: 1 January 2019