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ACS Applied Energy Materials

ACS Applied Energy Materials

IF: 5.4
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Baloxavir Marboxil: An Original New Drug against Influenza.

Published:24 December 2021 DOI: 10.3390/ph15010028 PMID: 35056085
Fran?ois Dufrasne

Abstract

Baloxavir marboxil is a new drug developed in Japan by Shionogi to treat seasonal flu infection. This cap-dependent endonuclease inhibitor is a prodrug that releases the biologically active baloxavir acid. This new medicine has been marketed in Japan, the USA and Europe. It is well tolerated (more than 1% of the patients experienced diarrhea, bronchitis, nausea, nasopharyngitis, and headache), and both influenza A and B viruses are sensitive, although the B strain is more resistant due to variations in the amino acid residues in the binding site. The drug is now in post-marketing pharmacovigilance phase, and its interest will be especially re-evaluated in the future during the annual flu outbreaks. It has been also introduced in a recent clinical trial against COVID-19 with favipiravir.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
Favipiravir 259793-96-9 C5H4FN3O2 543 suppliers $5.00-$2000.00
Baloxavir marboxil 1985606-14-1 C27H23F2N3O7S 298 suppliers Inquiry
Baloxavir 1985605-59-1 C24H19F2N3O4S 208 suppliers Inquiry
Baloxavir acid - Inquiry

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