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ACS Applied Energy Materials

ACS Applied Energy Materials

IF: 5.4
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A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives.

Published:3 November 2021 DOI: 10.3389/fphar.2021.762807 PMID: 34803707
Shejuti Rahman Brishty,?Md Jamal Hossain,?Mayeen Uddin Khandaker,?Mohammad Rashed Iqbal Faruque,?Hamid Osman,?S M Abdur Rahman

Abstract

Nowadays, nitrogenous heterocyclic molecules have attracted a great deal of interest among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole scaffolds are considerably prevalent. Due to their isostructural pharmacophore of naturally occurring active biomolecules, benzimidazole derivatives have significant importance as chemotherapeutic agents in diverse clinical conditions. Researchers have synthesized plenty of benzimidazole derivatives in the last decades, amidst a large share of these compounds exerted excellent bioactivity against many ailments with outstanding bioavailability, safety, and stability profiles. In this comprehensive review, we have summarized the bioactivity of the benzimidazole derivatives reported in recent literature (2012-2021) with their available structure-activity relationship. Compounds bearing benzimidazole nucleus possess broad-spectrum pharmacological properties ranging from common antibacterial effects to the world's most virulent diseases. Several promising therapeutic candidates are undergoing human trials, and some of these are going to be approved for clinical use. However, notable challenges, such as drug resistance, costly and tedious synthetic methods, little structural information of receptors, lack of advanced software, and so on, are still viable to be overcome for further research.

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