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Toxicology letters

Toxicology letters

IF: 2.89
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Urinary metabolites of the UV filter 2-Ethylhexyl salicylate as biomarkers of exposure in humans

Published:1 July 2019 DOI: 10.1016/j.toxlet.2019.04.001 PMID: 30953687
Daniel Bury , Peter Griem , Tanja Wildemann , Thomas Brüning , Holger M. Koch

Abstract

The UV filter 2-ethylhexyl salicylate (EHS) is used in sunscreens and other personal care products worldwide and has been found in a variety of environmental media. We aimed to provide human toxicokinetic data on EHS as a tool for risk assessment. For that purpose, we investigated metabolism and urinary metabolite excretion after a single oral EHS dose (57.4–75.5?μg/(kg body weight)) in three male volunteers. In a suspect screening, we tentatively identified seven EHS metabolites. Three EHS specific metabolites were quantitatively investigated: 2-ethyl-5-hydroxyhexyl 2-hydroxybenzoate (5OH-EHS), 2-ethyl-5-oxohexyl 2-hydroxybenzoate (5oxo-EHS), and 5-(((2-hydroxybenzoyl)oxy)methyl)heptanoic acid (5cx-EPS). These metabolites were excreted with urinary excretion fractions of 0.28% (range: 0.13?0.54%), 0.11% (0.06?0.20%), and 0.24% (0.14?0.41%), respectively. The elimination was fast: peak urinary concentrations were found 1.6–2.6?h after dose and ≥95% of the total amounts were excreted within 24?h. Elimination kinetics were biphasic, with mean elimination half-lives of 0.8?h (first phase) and 6.6?h (second phase) for 5OH-EHS, 0.8?h and 6.3?h for 5oxo-EHS, and 1.1?h and 5.9?h for 5cx-EPS. After dermal exposure (sunscreen application), we found a considerably delayed EHS elimination. Based on urinary metabolite levels we calculated EHS exposure levels for a small pilot population.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
2-Ethylhexyl salicylate 118-60-5 C15H22O3 471 suppliers $12.00-$6728.34
Phosphoric acid, 2-ethyl-5-hydroxyhexyl diphenyl ester 2173149-33-0 C20H27O5P 4 suppliers Inquiry
1-(2-Ethyl-5-oxohexyl)hydrogen 1,4-Benzenedicarboxylate 1684398-40-0 C16H20O5 2 suppliers Inquiry

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