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ACS Applied Bio Materials

ACS Applied Bio Materials

IF: 4.59
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Glycyrrhizic acid in the treatment of liver diseases: literature review.

Published:1 January 2014 DOI: 10.1155/2014/872139 PMID: 24963489
Jian-yuan Li, Hong-yan Cao, Ping Liu, Gen-hong Cheng, Ming-yu Sun

Abstract

Glycyrrhizic acid (GA) is a triterpene glycoside found in the roots of licorice plants (Glycyrrhiza glabra). GA is the most important active ingredient in the licorice root, and possesses a wide range of pharmacological and biological activities. GA coupled with glycyrrhetinic acid and 18-beta-glycyrrhetic acid was developed in China or Japan as an anti-inflammatory, antiviral, and antiallergic drug for liver disease. This review summarizes the current biological activities of GA and its medical applications in liver diseases. The pharmacological actions of GA include inhibition of hepatic apoptosis and necrosis; anti-inflammatory and immune regulatory actions; antiviral effects; and antitumor effects. This paper will be a useful reference for physicians and biologists researching GA and will open the door to novel agents in drug discovery and development from Chinese herbs. With additional research, GA may be more widely used in the treatment of liver diseases or other conditions.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
18β-Glycyrrhetinic Acid 471-53-4 C30H46O4 600 suppliers $19.80-$3176.25
Glycyrrhizic acid 1405-86-3 C42H62O16 569 suppliers $10.00-$1110.00

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