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Advanced Science

Advanced Science

IF: 14.3
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High Spatiotemporal Near‐Infrared II Fluorescence Lifetime Imaging for Quantitative Detection of Clinical Tumor Margins

Published:9 December 2024 DOI: 10.1002/advs.202411272 PMID: 39652447
Zhen Chen,?Linjian Huang,?Duyang Gao,?Zhouzhou Bao,?Dehong Hu,?Wei Zheng,?Jing Chen,?Jiuling Liao,?Hairong Zheng,?Zonghai Sheng

Abstract

Accurate detection of tumor margins is essential for successful cancer surgery. While indocyanine green (ICG)-based near-infrared (NIR) fluorescence (FL) surgical navigation enhances the visual identification of tumor margins, its accuracy remains subjective, underscoring the need for quantitative approaches. In this study, a high spatiotemporal fluorescence lifetime (FLT) imaging technology is developed in the second near-infrared window (NIR-II, 1000-1700?nm) for quantitative tumor margin detection, utilizing folate receptor-targeted ICG nanoprobes (FPH-ICG). FPH-ICG exhibits a significantly prolonged NIR-II FLT (750 ±?7?ps vs 260 ±?3?ps) and increased NIR-II FL brightness (FPH-ICG/ICG?=?3.8). In vitro and in vivo studies confirm that FPH-ICG specifically targets folate receptor-α (FRα) on SK-OV-3 ovarian cancer cells, achieving high-contrast NIR-II FL imaging with a signal-to-background ratio of 10.8. Notably, NIR-II FLT imaging demonstrates superior accuracy (90%) and consistency in defining tumor margins compared to NIR-II FL imaging (58%) in both SK-OV-3 tumor-bearing mice and clinical tumor samples. These findings underscore the potential of NIR-II FLT imaging as a quantitative tool for guiding surgical tumor margin detection.

Substances (2)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Indocyanine green 3599-32-4 C43H49N2NaO6S2 374 suppliers $38.00-$943.00
FETUIN 9014-81-7 NULL 66 suppliers $37.07-$4380.00