天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook >> journal list >> Chemical Engineering Journal >>article
Chemical Engineering Journal

Chemical Engineering Journal

IF: 13.3
Download PDF

Tea leaf-derived nanovesicles for ferric-supply-amplified ICD and macrophage reprogramming to boost immunotherapy against head and neck squamous carcinoma

Published:9 December 2024 DOI: 10.1016/j.cej.2024.158469
Hanzhe Liu, Zhenan Liu, Weilian Liang, Hokeung Tang, Lili Yu, Tong Wang, Lan Liu, Qingli Chen, Jia-Wei Wang, Xian-Zheng Zhang, Guo-Feng Luo, Zhengjun Shang

Abstract

Combination of multiple immune activation pathways that can modulate different immune axes in coordination has been found extremely effective in amplifying immunotherapy. In this study, by using a naturally occurring tea leaf-derived nanovesicles (TDNVs), we prepare an all-in-one multifunctional immunotherapeutic nanomedicine (denoted as DFeTNVs) by co-loading chemotherapeutic drug doxorubicin (DOX) into a ferric-engineered TDNVs. Owing to the acid-triggered responsiveness, the loaded cargoes (DOX and Fe3+) would be released in the tumor acidic microenvironment to elicit DOX-mediated immunogenic cell death (ICD) that is further enhanced by the ferric ions-mediated Fenton reaction. Strikingly, the inherent surface galactose of DFeTNVs could promote specific cellular uptake of macrophages through galactose-type lectin-mediated endocytosis, so as to deliver Fe3+ inside macrophages for potentiating the polarization of M2-like tumor-associated macrophages (TAMs) into M1 phenotype, thereby boosting the macrophage-mediated phagocytosis and T cell activation. All these contribute to evoke a strong anticancer immune response, especially in combination with anti-PD-L1 antibody, to inhibit tumor growth. The present work provides a delicate design integrated with multiple functions (i.e., drug loading, metal chelation, intrinsic targeting) without using excessive chemical ligands or complex synthetic processes, promising the feasibility of this immunotherapeutic nanosystem for future clinical applications.

Substances (5)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Doxorubicin hydrochloride 25316-40-9 C27H29NO11.ClH 790 suppliers $20.00-$2052.00
(-)-Epicatechin gallate 1257-08-5 C22H18O10 403 suppliers $28.00-$1963.50
Deoxyribonuclease 9003-98-9 NULL 289 suppliers $58.00-$2170.00
D-(+)-GALACTOSE 10257-28-0 C6H12O6 81 suppliers $138.00-$490.00
FETUIN 9014-81-7 NULL 67 suppliers $37.07-$4380.00

Similar articles

IF:10

Hybrid Cell Membrane‐Coated Nanoparticles for Synergizing Sonodynamic Therapy and Immunotherapy against Triple‐Negative Breast Cancer

Advanced Healthcare Materials Jiali Gong, Danling Cheng,etc Published: 21 November 2024
IF:4.8

Ferric pyrophosphate: good things come to those who wait?

Nephrology Dialysis Transplantation Lisa H Fell, Danilo Fliser,etc Published: 1 December 2015
IF:16.4

Efficacy and Safety of Microsomal Ferric Pyrophosphate Supplement for Iron Deficiency Anemia in Pregnancy

Accounts of Chemical Research Ankita Srivastav, Shilpa Kshirsagar,etc Published: 28 March 2024