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Langmuir

Langmuir

IF: 3.7
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Application of a Near-Infrared Fluorescence Probe Based on Perylene Bisimide in the Detection of Heparin

Published:5 December 2024 DOI: 10.1021/acs.langmuir.4c03578
Yueji Li, Yuteng Zhang, Xue Liu, Bin Dong, Pan Xu, Bo Song

Abstract

Heparin is widely used to treat thrombosis because it is an effective anticoagulant. However, excessive use of heparin can lead to an increased risk of bleeding, which makes the quantitative detection of heparin very important. An amphiphilic perylene bisimide molecule (denoted PBI-9) was developed, which presented a near-infrared emission peak at 730 nm when it was aggregated. PBI-9 has been utilized in the detection of heparin, as the pyridine cation in PBI-9 binds strongly to highly sulfated heparin through electrostatic interactions. Charge neutralization triggers the self-assembly of PBI-9, which leads to an emission peak shift from 540 nm to 690 nm, corresponding to monomeric emission to excimer emission. This shift was applied for the detection of heparin. Importantly, the interaction between PBI-9 and heparin is not affected by protamine, resulting in high selectivity and minimal interference. PBI-9 is a promising tool for detecting heparin in clinical settings after excess heparin has been neutralized by protamine.

Substances (24)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Ascorbic Acid 50-81-7 C6H8O6 1631 suppliers $6.00-$2170.00
Sodium carbonate 497-19-8 CH2O3.2Na 1497 suppliers $14.00-$4640.00
Potassium chloride 7447-40-7 KCl 1311 suppliers $6.00-$11230.00
4-Dimethylaminopyridine 1122-58-3 C7H10N2 1239 suppliers $6.00-$5370.00
Sodium chloride 7647-14-5 ClNa 1216 suppliers $5.00-$6678.62
Sodium hydroxide 1310-73-2 NaOH 1212 suppliers $14.00-$16472.00
Imidazole 288-32-4 C3H4N2 1179 suppliers $5.00-$19203.00
Glutathione 70-18-8 C10H17N3O6S 1138 suppliers $6.00-$3420.00
L-Glutamic acid 56-86-0 C5H9NO4 973 suppliers $5.00-$6413.62
Calcium chloride 10043-52-4 CaCl2 946 suppliers $5.00-$26371.00

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