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Advanced Science

IF: 14.3
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Spatial Transcriptome and Single Nucleus Transcriptome Sequencing Reveals Tetrahydroxy Stilbene Glucoside Promotes Ovarian Organoids Development Through?…

Published:4 December 2024 DOI: 10.1002/advs.202410098 PMID: 39629971
Chunlan Mu,?Xiaoyong Li,?Jiamei Yang,?Geng G Tian,?Hepeng Bai,?Wenhui Lin,?Linhui Wang,?Ji Wu

Abstract

Ovarian dysfunction is a major factor leading to female infertility. Understanding how to improve or reshape ovarian function has become an important entry point for preventing and treating female infertility caused by ovarian dysfunction. Here, plant-derived compounds are screened for in vitro activity upon ovarian organoids derived from feeder-free female germline stem cells. Tetrahydroxy stilbene glucoside (TSG) is found to promote the development of ovarian organoids. Single nucleus transcriptome sequencing and spatial transcriptome sequencing are used to establish a comprehensive spatiotemporal map to elucidate the role of TSG in ovarian organoid development, encompassing cell types and subtypes, transcription factors, pseudo-time sequence, and cell communication dynamics. This analysis indicates that TSG promotes ovarian organoid development through the vascular endothelial growth factor A-Eph receptor B2 ligand-receptor pair between granulosa cells and oocytes. This study has enhanced the understanding of the mechanisms of ovarian organoid development, establishes a technical platform for screening compounds for treating infertility and related diseases, and lays a foundation for clinically applying plant-derived compounds.

Substances (7)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Curcumin 458-37-7 C21H20O6 1022 suppliers $5.00-$1280.00
Apigenin 520-36-5 C15H10O5 711 suppliers $5.00-$1363.36
Phloretin 60-82-2 C15H14O5 479 suppliers $6.00-$2055.90
Ginsenoside Rg1 22427-39-0 C42H72O14 378 suppliers $9.00-$1295.00
Leonurine hydrochloride 24697-74-3 C14H21N3O5 294 suppliers $49.00-$2395.30
Notopterol 88206-46-6 C21H22O5 162 suppliers $45.00-$1647.00
2-(3,4-Dihydroxyphenyl)-2-((2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl)oxy)chroman-3,4,5,7-tetraol 20347-71-1 C30H26O13 41 suppliers $5.00-$480.00

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