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IF: 27.39
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Biomimetic Nanomotors for Deep Ischemia Penetration and Ferroptosis Inhibition in Neuroprotective Therapy of Ischemic Stroke

Published:26 November 2024 DOI: 10.1002/adma.202409176 PMID: 39600046
Rui Wang, Weimin Nie, Xin Yan, Kuankuan Luo, Qi Zhang, Tao Wang, Enhao Lu, Yiting Chen, Yu Luo, Zhiwen Zhang, He Wang, Jing Zhao, Xianyi Sha

Abstract

Nerve injury represents the primary reason of mortality and disability in ischemic stroke, but effective drug delivery to the region of cerebral ischemia and hypoxia poses a significant challenge in neuroprotective treatment. To address these clinical challenges, a biomimetic nanomotor, Pt@LF is designed, to facilitate deep delivery of neuroprotective agents and inhibit ferroptosis in ischemic stroke. Pt@LF traverses the blood-brain barrier (BBB) and penetrates into deep cerebral ischemic-hypoxic areas due to the active targeting capacity of apo-lactoferrin (Apo-LF) and the self-propelling motion properties of nanomotors. Subsequently, Pt@LF loosens thrombus and alleviates the "no reflow" phenomenon via mechanical thrombolysis. Thanks to the various enzyme-like abilities and multi-target ferroptosis inhibition capability, Pt@LF ameliorates the inflammatory microenvironment and rescues dying neurons. In conclusion, Pt@LF demonstrates efficiently deep penetration and neuroprotective effects in vitro and vivo. And this study provides a promising therapeutic platform for the treatment of ischemic stroke.

Substances (5)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Fluorescein isothiocyanate isomer I 3326-32-7 C21H11NO5S 386 suppliers $37.00-$8352.40
4',6-Diamidino-2-phenylindole dihydrochloride 28718-90-3 C16H16ClN5 294 suppliers $14.10-$4800.00
2′,7′-Dichlorodihydrofluorescein Diacetate 4091-99-0 C24H16Cl2O7 177 suppliers $33.00-$1947.00
RSL3 1219810-16-8 C23H21ClN2O5 122 suppliers $32.00-$1500.00
JC-1 3520-43-2 C25H27Cl4N4.I 100 suppliers $68.00-$3900.00

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