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Advanced Science

Advanced Science

IF: 14.3
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A Purely Biomanufactured System for Delivering Nanoparticles and STING Agonists

Published:26 November 2024 DOI: 10.1002/advs.202408539 PMID: 39588587
Yu‐an Li, Yi Feng, Wenjing Li, Yuqin Zhang, Yanni Sun, Shifeng Wang, Roy Curtiss, Huoying Shi

Abstract

Nanovaccines have significantly contributed in the prevention and treatment of diseases. However, most of these technologies rely on chemical or hybrid semibiological synthesis methods, which limit the manufacturing performance advantages and improved inoculation outcomes compared with traditional vaccines. Herein, a universal and purely biological nanovaccine system is reported. This system integrates three modules: (1) self-assembling nanoparticles, (2) self-catalyzed synthesis of small-molecule stimulator of interferon gene (STING) agonists, and (3) delivery vectors that target the cytosolic surveillance system. Various nanoparticles are efficiently self-assembled using this system. After confirming the excellent immunostimulatory and lymph node targeting of this system, its broad-spectrum antiviral efficacy is further demonstrated. By leveraging the comprehensive biosynthetic capabilities of bacterial cells, this system can efficiently combine various adjuvant-active modular components and antigenic cargo, thereby providing a highly diversified and potent vaccine platform.

Substances (2)

Materials
Procduct Name CAS Molecular Formula Supplier Price
IPTG 367-93-1 C9H18O5S 807 suppliers $5.00-$30622.00
Lactose 63-42-3 C12H22O11 590 suppliers $36.00-$875.00

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