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Discover the mysterious skincare "little guard": the magical journey of 2-Methyl-4-isothiazolin-3-one

Oct 22,2024

Abstract

In our daily lives, whether it is facial cleanser, shower gel, sunscreen, or hair conditioner, we cannot leave a small guardian that silently guards our skin health - preservatives. Among these preservatives, 2-Methyl-4-isothiazolin-3-one(MIT) has become a concerned role because of its unique bactericidal effect and wide range of applications.

2-Methyl-4-isothiazolin-3-one

Introduction

2-Methyl-4-isothiazolin-3-one(MIT) is an organic compound with the chemical formula C?H?NOS and a molecular weight of 115.15. This white-to-yellow powdery substance, with a certain smell, has amazing bactericidal power. As an efficient, broad-spectrum fungicide, it can inhibit the growth of bacteria, fungi, mold, and other microorganisms, and protect our skin health.

Uses

2-Methyl-4-isothiazolin-3-one (MIT), finds application in domestic and I & I cleaners, whereas the same product in combination with 5-chloro-2-methyl-4-isothiazolin-3-one (CIT) is an established preservative in personal care and cosmetic products.

1,2-Benzisothiazolin-3-one (BIT) also has biocidal activity but is more commonly used in metal working/cutting oil applications.

Hazards

2-Methyl-4-isothiazolin-3-one (MIT) is allergenic and cytotoxic, and this has led to some concern over its use.A report released by the European Scientific Committee on Cosmetic Products and Non-food Products Intended for Consumers (SCCNFP) in 2003 also concluded that insufficient information was available to allow for an adequate risk assessment analysis of MIT.

References:

[1] SCHNUCH. Patch testing with preservatives, antimicrobials and industrial biocides. Results from a multicentre study[J]. British Journal of Dermatology, 2002, 138 3: 381-565. DOI:10.1046/j.1365-2133.1998.02126.x.

[2] A C DE GROOT A H. Isothiazolinone preservative: cause of a continuing epidemic of cosmetic dermatitis.[J]. The Lancet, 1989, 1 8633. DOI:10.1016/s0140-6736(89)91318-4.

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2-Methyl-4-isothiazolin-3-one manufacturers

  • Methylisothiazolinone
  • 2682-20-4 Methylisothiazolinone
  • $55.00 / 1kg
  • 2025-01-23
  • CAS:2682-20-4
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 20 tons
  • Methylisothiazolinone
  • 2682-20-4 Methylisothiazolinone
  • $0.00 / 1KG
  • 2025-01-20
  • CAS:2682-20-4
  • Min. Order: 1KG
  • Purity: 98%min
  • Supply Ability: 30tons/month