頭孢噻吩鈉 TEL: 18062666980 【性狀】 本品為白色或類白色的結(jié)晶性粉末；幾乎無臭。 本品在水中易溶，在乙醇中微溶，在氯仿或乙醚中不溶。 比旋度 取本品，精密稱定，加水溶解并稀釋制成每1ml 中含10mg的溶液，在 25℃時(shí)，依法測定（附錄Ⅵ E），比旋度為+124°至+134°。 【鑒別】 (1)在含量測定項(xiàng)下記錄的色譜圖中，供試品主峰的保留時(shí)間應(yīng)與頭孢噻吩 對照品主峰的保留時(shí)間一致。 (2) 本品的紅外光吸收圖譜應(yīng)與對照的圖譜（光譜集129 圖）一致。 (3) 本品顯鈉鹽的火焰反應(yīng)（附錄Ⅲ）。 【檢查】 酸度 取本品，加水制成每1ml中含0.1g的溶液，依法測定（附錄Ⅵ H ），pH值應(yīng)為4.5～7.0 。 溶液的澄清度與顏色 取本品5 份，各0.6g，分別加水5ml 溶解后，溶液應(yīng)澄清無 色；如顯渾濁，與1 號濁度標(biāo)準(zhǔn)液（附錄Ⅸ B）比較，均不得更濃；如顯色，與黃色或 黃綠色5號標(biāo)準(zhǔn)比色液（附錄Ⅸ A法）比較，均不得更深。 吸收度 取本品，加水制成每1ml 中含20μg 的溶液，照分光光度法（附錄Ⅳ A）， 在237nm 的波長處測定，其吸收度為0.65～0.72。 水分 取本品，照水分測定法（附錄Ⅷ M法A）測定，含水分不得過1.2％。 熱原 取本品，加滅菌注射用水制成每1ml中含50mg的溶液，依法檢查（附錄Ⅺ D ），劑量按家兔體重每1Kg 注射1ml ，應(yīng)符合規(guī)定。 無菌 取本品，分別加入100ml 0.9％無菌氯化鈉溶液中使溶解，用薄膜過濾法處理后， 依法檢查（附錄Ⅺ H），應(yīng)符合規(guī)定。 【含量測定】 照高效液相色譜法（附錄Ⅴ D）測定。 色譜條件與系統(tǒng)適用性試驗(yàn) 用十八烷基硅烷鍵合硅膠為填充劑；醋酸溶液（1→100） -乙腈（3:1）為流動相；檢測波長為254nm。調(diào)節(jié)流速使頭孢噻吩峰的保留時(shí)間約勻?yàn)?分鐘。 測定法 取本品適量，精密稱定，加水溶解并制成每1ml中約含0.5mg的溶液，取10μl 注入液相色譜儀，記錄色譜圖；另取頭孢噻吩對照品適量，同法測定。按外標(biāo)法以峰面積計(jì)算 出供試品中C16H16N2O6S2的含量。 【類別】 抗生素類藥。 【貯藏】 嚴(yán)封，在涼暗干燥處保存。 【制劑】 注射用頭孢噻吩鈉 195 C16H15N2O6S2 418.43 Cymbalta (6R, 7R) -3 - [(acetyloxy) methyl] -7 - [2 - (2 - thiophene-yl) acetamido]-8 - oxo - sulfur Oxa-1 - azabicyclo [4.2.0] oct-2 - ene - 2 - sodium salt. Calculated on the anhydrous containing Cefalotin (C16H16N2O 6S2) shall not be less than 90.0%. 【Properties】 white or off-white crystalline powder; almost odorless. This product is soluble in water, slightly soluble in ethanol, insoluble in chloroform or ether. Specific rotation to take this product, accurately weighed, dissolved in water and diluted per 1ml contains 10mg solution in Determination in accordance with the law (Appendix Ⅵ E), 25 ℃ Specific rotation +124 ° to +134 °. Identification (1) Determination under-recorded chromatogram, the retention time of the main peak of the test should be Cefalotin Of standard main peak in the same retention time. (2) The product of the infrared absorption spectrum should control spectra (spectral set of 129). (3) This product was sodium salt of the flame reaction (Appendix III). [Check] acidity to take this product, add water containing 0.1 g solution per 1ml, measured according to the law (Appendix VI H ), PH value of 4.5 to 7.0. Clarity and color of solution is to take this product, each 0.6g, 5ml of water dissolved, the solution should be clarified without Color; significant turbidity, compared with the 1st turbidity standard solution (Appendix Ⅸ B), shall be thicker; such as color, with yellow or Yellow-green on the 5th standard colorimetric solution (Appendix Ⅸ A first method), shall not be deeper. Absorbance of this product, the addition of water per 1ml containing 20μg solution, according to spectrophotometry (Appendix Ⅳ A) 237 nm at a wavelength of determination, the absorbance of 0.65 to 0.72. The moisture of this product, measured according to the determination of moisture content (Appendix Ⅷ M and A) on the Law of water containing not more than 1.2%. The pyrogen to take this product, add sterile water for injection containing 50 mg solution per 1ml, according to the law check (Ⅺ D Appendix ), The dose per of 1Kg injection 1 ml of rabbit weight should be required. Sterile to take this product were added to 100ml 0.9% sterile sodium chloride solution to dissolve after treatment with membrane filtration method , Shall comply with the provisions of the law examination (Appendix XI H). 【Assay for high performance liquid chromatography (Appendix Ⅴ D). Determination. Chromatographic conditions and system suitability test together with Octadecylsilanized silica as a filler; acetic acid solution (1 → 100) - Acetonitrile (3:1) as the mobile phase; detection wavelength was 254 nm. The flow rate was adjusted to make Cefalotin peak retention time is approximately uniform for 7 minutes. Take some assay, accurately weighed, dissolved in water and the solution containing 0.5mg per 1ml about, take 10μl Into the liquid chromatograph, record the chromatogram; Another Cefalotin appropriate reference, the same method. Peak area of ??the external standard method Out the test C16H16N2O6S2 content. 【Category】 antibiotic medicines. 【Storage】 strict closure stored in a cool dark dry place. [Preparations] for injection Cephalothin sodium 武漢遠(yuǎn)城科技發(fā)展有限公司位于風(fēng)景秀麗的首義創(chuàng)新生化工業(yè)園，是中南地區(qū)大型的專業(yè)從事精細(xì)化工，香精香料，食品添加劑，醫(yī)藥原料及中間體等產(chǎn)品的研究，開發(fā)，生產(chǎn)，經(jīng)營，銷售于一體的高科技化工企業(yè)。 公司屬中南地區(qū)大型的專業(yè)從事精細(xì)化工，食品添加劑，醫(yī)藥原料及中間體等產(chǎn)品的研究、開發(fā)、生產(chǎn)、銷售于一體的高科技化工集團(tuán)公司。 公司固定資產(chǎn)總投資資已達(dá)成1億余元，擁有按GMP標(biāo)準(zhǔn)建造從中試到大生產(chǎn)，設(shè)備先進(jìn)，配套齊全的10000余平方米生產(chǎn)車間；擁有完善的質(zhì)量保證體系和健全質(zhì)量控制制度；擁有多套高壓液相色譜儀，氣相色譜儀和紫外分光光度計(jì)等高效高靈敏度的分析儀器，對產(chǎn)品進(jìn)行有效的分析和監(jiān)控。公司已通過ISO9001質(zhì)量體系認(rèn)證。 公司擁有進(jìn)出口自主權(quán),公司生產(chǎn)的肉桂系列產(chǎn)品:肉桂酸、肉桂醛、肉桂醇、維生素E、維生素B1以及生物化工、醫(yī)藥中間體等產(chǎn)品暢銷全國各地并出口到歐美及東南亞20多個(gè)國家和地區(qū)，深受客戶好評。 公司投入巨資和人力用于研發(fā)適應(yīng)市場需求的精細(xì)化工，生物化工，醫(yī)藥中間體等新產(chǎn)品，新工藝。高水平的研發(fā)團(tuán)隊(duì)，一流的實(shí)驗(yàn)設(shè)備，良好的科研氛圍保證了研發(fā)實(shí)力，目前生產(chǎn)的產(chǎn)品，全部由本公司自行研究開發(fā)，達(dá)到了國內(nèi)先進(jìn)水平，部分產(chǎn)品達(dá)到國際先進(jìn)水平。 公司堅(jiān)持"以人為本，科技領(lǐng)先，遠(yuǎn)城服務(wù)，誠信永遠(yuǎn)"的服務(wù)宗旨。以質(zhì)量求生存;以服務(wù)創(chuàng)效益;以法紀(jì)立信。 其他相關(guān)產(chǎn)品 [供]左旋肉堿？[供]左旋肉堿酒石酸鹽? 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