ASLAN003 是一種具有口服活性，有效的二氫乳清酸脫氫酶 (DHODH) 抑制劑，對人 DHODH 酶的 IC₅₀ 為 35 nM。ASLAN003 通過激活 AP-1 轉(zhuǎn)錄因子來抑制蛋白質(zhì)合成。ASLAN003 可以誘導(dǎo)凋亡 (apoptosis)，并在急性髓樣白血病 (AML) 異種移植小鼠中大大延長其生存期。ASLAN003 is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC₅₀ of 35 nM for human DHODH enzyme. ASLAN003 inhibits protein synthesis via activation of AP-1 transcription factors. ASLAN003 induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice