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克霉唑,Clotrimazole
  • 克霉唑,Clotrimazole

克霉唑

價(jià)格 詢價(jià)
包裝 25Kg/Drum
最小起訂量 25Kg
發(fā)貨地 湖北
更新日期 2020-11-10

產(chǎn)品詳情

中文名稱:克霉唑英文名稱:Clotrimazole
CAS:23593-75-1產(chǎn)品類別: boshan
2020-11-10 克霉唑 Clotrimazole 25Kg/Drum/RMB boshan

Clotrimazole CAS 23593-75-1

CP/USP/BP/EP 25kg/DRUM

Clotrimazole Structure
Clotrimazole structure
 
 Common Name Clotrimazole
CAS Number 23593-75-1 Molecular Weight 344.837
Density 1.1±0.1 g/cm3 Boiling Point 482.3±40.0 °C at 760 mmHg
Molecular Formula C22H17ClN2 Melting Point 147-149ºC
MSDS ChineseUSA Flash Point 245.5±27.3 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Clotrimazole


Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor.Target: Antifungal; CYPClotrimazole (brand name Canesten or Lotrimin) is an antifungal medication commonly used in the treatment of fungal infections (of both humans and other animals) such as vaginal yeast infections, oral thrush, and ringworm. It is also used to treat athlete's foot and jock itch.It is commonly available as an over-the-counter substance in various dosage forms, such as a cream, and also (especially in the case of ear infection) as a combination medicine. It is also available as a troche or throat lozenge (prescription only). For ear infection, it is often applied in liquid form, as ear drops.The antimycotic drug clotrimazole inhibits the function of the gastric H,K-ATPase in a manner similar to that observed for the Na,K-ATPase. Because of the high hydrophobicity of the compound, the interaction between clotrimazole and the ion pump occurs at the membrane domain in the apolar core of the membrane. The enzymatic activity was inhibited with a half-saturating concentration of 5.2 microM. Various partial reactions of the pump cycle were analyzed with the electrochromic styryl dye RH421 that has been widely used to study the transport mechanism of P-type ATPases.

 Names

Name clotrimazole
Synonym More Synonyms

 Clotrimazole Biological Activity

Description Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor.Target: Antifungal; CYPClotrimazole (brand name Canesten or Lotrimin) is an antifungal medication commonly used in the treatment of fungal infections (of both humans and other animals) such as vaginal yeast infections, oral thrush, and ringworm. It is also used to treat athlete's foot and jock itch.It is commonly available as an over-the-counter substance in various dosage forms, such as a cream, and also (especially in the case of ear infection) as a combination medicine. It is also available as a troche or throat lozenge (prescription only). For ear infection, it is often applied in liquid form, as ear drops.The antimycotic drug clotrimazole inhibits the function of the gastric H,K-ATPase in a manner similar to that observed for the Na,K-ATPase. Because of the high hydrophobicity of the compound, the interaction between clotrimazole and the ion pump occurs at the membrane domain in the apolar core of the membrane. The enzymatic activity was inhibited with a half-saturating concentration of 5.2 microM. Various partial reactions of the pump cycle were analyzed with the electrochromic styryl dye RH421 that has been widely used to study the transport mechanism of P-type ATPases.
Related Catalog
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> Anti-infection >> Fungal
Research Areas >> Infection
References

[1]. Sawyer PR, Clotrimazole: a review of its antifungal activity and therapeutic efficacy. Drugs. 1975;9(6):424-47.

[2]. Witzke A, Inhibition of the gastric H,K-ATPase by clotrimazole. Biochemistry. 2010 Jun 1;49(21):4524-32.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 482.3±40.0 °C at 760 mmHg
Melting Point 147-149ºC
Molecular Formula C22H17ClN2
Molecular Weight 344.837
Flash Point 245.5±27.3 °C
Exact Mass 344.108032
PSA 17.82000
LogP 5.44
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.617
Storage condition Store at RT.
Water Solubility Soluble in chloroform, DMSO, DMF and alcohols
 
 
 

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關(guān)鍵字： Clotrimazole;Clotrimazole;Clotrimazole;

公司簡(jiǎn)介

九州通是一家以西藥、中藥、器械為主要經(jīng)營(yíng)產(chǎn)品，以醫(yī)療機(jī)構(gòu)、批發(fā)企業(yè)、零售藥店為主要客戶對(duì)象，并為客戶提供信息、物流等各項(xiàng)增值服務(wù)的大型企業(yè)集團(tuán)。公司立足于醫(yī)藥健康行業(yè)，是中國(guó)醫(yī)藥商業(yè)領(lǐng)域具有全國(guó)性網(wǎng)絡(luò)的少數(shù)幾家企業(yè)之一，于2010年11月2日在上海證券交易所掛牌上市（股票簡(jiǎn)稱：九州通，證券代碼：600998），公司連續(xù)多年位列中國(guó)醫(yī)藥商業(yè)企業(yè)第四位，領(lǐng)跑中國(guó)民營(yíng)醫(yī)藥商業(yè)企業(yè)，2020年位列《財(cái)富》（中文版）500強(qiáng)第100位。 九州通成立于1999年3月，總部位于湖北省武漢市。截止2020年9月30日，公司注冊(cè)資本18.78億元，總資產(chǎn)787.17億元。實(shí)現(xiàn)營(yíng)業(yè)收入803.20億元，凈利潤(rùn)21.41億元，分別較上年同期增長(zhǎng)9.46%和110.23％?？鄢墙?jīng)常性損益后歸屬于上市公司股東的凈利潤(rùn)為12.52億元，較上年同期增長(zhǎng)45.12%。2019年公司實(shí)現(xiàn)營(yíng)業(yè)收入994.97億元，歸屬于上市公司股東的凈利潤(rùn)17.81億元，分別較上年同期增長(zhǎng)14.19%和28.96%。員工兩萬五千余人。直營(yíng)和加盟零售連鎖藥店1074家。
成立日期 1999-03-09 （26年） 注冊(cè)資本 1877663513
員工人數(shù) 500人以上 年?duì)I業(yè)額 ￥ 1億以上
主營(yíng)行業(yè) 醫(yī)藥中間體,原料藥,獸藥原料,維生素類 經(jīng)營(yíng)模式 貿(mào)易,工廠
  • 九州通醫(yī)藥集團(tuán)股份有限公司
非會(huì)員
  • 公司成立：26年
  • 注冊(cè)資本：1877663513
  • 企業(yè)類型：私營(yíng)
  • 主營(yíng)產(chǎn)品：枸櫞酸他莫昔芬 克霉唑 奮乃靜 硝酸異山梨酯 鹽酸美西律 托吡卡胺
  • 公司地址：號(hào)漢陽區(qū)龍陽大道特
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