AVN-492 is a potent and selective 5-HT6R Antagonist. The affinity of AVN-492 to bind to 5-HT6R (Ki?=?91 pM) was more than three orders of magnitude higher than that to bind to the only other target, 5-HT2BR, (Ki?=?170 nM). AVN-492 demonstrates good in vitro and in vivo ADME profile with high oral bioavailability and good brain permeability in rodents.
臺州市科瑞生物技術(shù)有限公司
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