Name

Recombinant Murine I-TAC/CXCL11 (Recombinant Murine I-TAC/CXCL11; rMuI-TAC/CXCL11)；Recombinant Mouse I-TAC/CXCL11 ; 重組小鼠干擾素誘導(dǎo)T細(xì)胞趨化物I-TAC/CXCL11

Synonyms

beta-R1; H174; I-TAC; SCYB9B; Beta-R1; b-R1; chemokine (C-X-C motif) ligand 11; H174IP9; Interferon gamma-inducible protein 9; Interferon-inducible T-cell alpha chemoattractant; IP-9member 11; ITAC; I-TACMGC102770; small inducible cytokine subfamily B (Cys-X-Cys), member 9B; Small-inducible cytokine B11

Purity

>98% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using murine CXCR3 transfected 293 cells is in a concentration of 10-100ng/ml.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in 10mM Sodium Citrate, pH4.0, with 600mM NaCl.

Endotoxin

Less than 1EU/μg of rMuI-TAC/CXCL11 as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Chemokines

Background

CXCL11 also known as I-TAC is belonging to the CXC chemokine family and shares 36% and 37% amino acid sequence homology with IP-10 and MIG, respectively. It is highly expressed in peripheral blood leukocytes, pancreas and liver. Expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3, which with a higher affinity than do the other chemokines for this receptor, CXCL9 and CXCL10. Similar to CXCL10, CXCL11 has been shown to be a chemoattractant for IL-2-activated T-lymphocytes, but not for isolated T-cells, neutrophils or monocytes.

Amino Acid Sequence

FLMFKQGRCL CIGPGMKAVK MAEIEKASVI YPSNGCDKVE VIVTMKAHKR QRCLDPRSKQ ARLIMQAIEK KNFLRRQNM

產(chǎn)品編號(hào)

產(chǎn)品名稱

包裝

KL-6744-5μg

Recombinant Murine I-TAC/CXCL11

5μg

KL-6744-20μg

Recombinant Murine I-TAC/CXCL11

20μg

KL-6744-100μg

Recombinant Murine I-TAC/CXCL11

100μg

KL-6744-1mg

Recombinant Murine I-TAC/CXCL11

1mg

-

說(shuō)明書(shū)

1份