ProSci Incorporated 於1998年成立于世界生物城之一的美國加州圣地亞哥市，是世界最早和的細(xì)胞凋亡抗體生產(chǎn)廠家和供應(yīng)商，公司現(xiàn)擁有17000多種單、多克隆抗體，產(chǎn)品涵蓋了細(xì)胞凋亡、信號轉(zhuǎn)導(dǎo)、免疫、腫瘤、細(xì)胞生物、神經(jīng)生物、傳染病等領(lǐng)域。ProSci公司的抗體大都經(jīng)免疫親和層析純化，經(jīng)過了嚴(yán)格的驗(yàn)證測試和質(zhì)量控制，具有高純度、高親和力、特異性強(qiáng)等特點(diǎn)，可用于免疫印跡（Western blot），免疫組織化學(xué)（IHC），免疫細(xì)胞化學(xué)（ICC），酶聯(lián)免疫吸附實(shí)驗(yàn)（ELISA）和細(xì)胞流式分析（FACS）等方面。ProSci的抗體產(chǎn)品已應(yīng)用在1281篇SCI論文中，其中2011年的有228篇，ProSci的經(jīng)銷商和客戶都對ProSci的產(chǎn)品質(zhì)量和服務(wù)十分滿意，ProSci公司在2003、2007、2010年度都被《Nature》評為免疫學(xué)試劑推薦品牌，抗體研發(fā)、生產(chǎn)和服務(wù)優(yōu)秀供應(yīng)商。
Bax Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bax, a pro-apoptotic Bcl-2 family member, is a cytosolic protein that changes conformation and translocates to the mitochondria following apoptotic stimuli. It is thought to share significant functional homology with Bak, another pro-apoptotic Bcl-2 family member, as disruption of bax or bak has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking both show decreased apoptotic capability.