Product name
NLRP3 Polyclonal Antibody
Isotype
IgG
Form
Lyophilized or Liquid
Tested applications
WB,IF,ELISA
Species reactivity
Human,Mouse,Rat
Host Species
Rabbit
Purity
Affinity purification
?
Immunogen Information:
Immunogen
Recombinant protein of human NLRP3
Calculated molecular weight
83kDa/105kDa/111kDa/112kDa/115kDa/118kDa
Observed molecular weight?
118kDa
Swiss Prot
Q96P20
Gene ID (NCBI)
114548
Alternative Names
NLRP3; AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1; FCAS; FCAS1; FCU; MWS; NALP3; PYPAF1; NLR family pyrin domain containing 3
Application Notes:
WB
1:200 - 1:1000
IF
1:50 - 1:200
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Western blot analysis of extracts of various cell lines, using NLRP3 antibody.
Immunofluorescence analysis of mouse lung using NLRP3 antibody.
Background:
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.?
Storage:
Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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