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抑制劑描述：
產(chǎn)品名稱：BIX-01294
產(chǎn)品別名：N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
英文別名：BIX 01294;BIX01294;BIX-01294
靶點(diǎn)：G9a
CAS：935693-62-2
純度：＞98%
外觀：Off-white solid
保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.
描述：
BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM.
溶解性：H2O : 14.29 mg/mL (29.13 mM; Need ultrasonic)
體外研究：
BIX-01294 (4.1 μM) treatment of G9anull ES cells results in a further reduction in H3K9me2 levels. BIX-01294 reduces H3K9me2 at several G9a target genes. BIX-01294 (5 µM) reduces levels of global H3K9 methylation in pronuclear- and 2-cell-stage embryos. Embryos transiently exposed to BIX-01294 have a reduced ability to establish pregnancy. BIX-01294 (1 µg/mL) causes reduction in the BrdU incorporation of fetal PASMCs. BIX-01294 treatment decreases the PASMCs migration induced by PDGF.
體內(nèi)研究：
產(chǎn)品信息訂購：
產(chǎn)品貨號
產(chǎn)品名稱
規(guī)格
價格
大包裝及貨期
abs810698
BIX-01294
5mg
1834
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