Phenylboronic acid is used in numerous cross coupling reactions. In 1979, Miyarura and Suzuki found a carbon-carbon bond forming reaction (now called a Suzuki reaction) using alkenyl boranes, aryl halides, catalytic Pd(0), and base to produce arylated alkene products. This method was generalized to a route producing biaryls by coupling phenylboronic acid with aryl halides.
More C-C bond forming processes commonly use phenylboronic acid as a reagent. Alpha-amino acids can be generated using the uncatalyzed reaction between alpha-ketoacids, amines, and phenylboronic acid. Heck-type cross coupling of phenylboronic acid to alkenes and alkynes. This unique C-C bond forming reaction has the ability to couple a terminal olefin with boronic acid using a transition metal catalyst. Aryl azides and nitroaromatics can also be generated using phenylboronic acid.PhB(OH)2 can be used as a protecting group for diols and diamines. Phenylboronic acid can also be regioselectively halodeboronated using aqueous bromine, chlorine, or iodine.
PhB(OH)2 + Br2 + H2O → PhBr + B(OH)3 + HBr
Phenylboronic acid is used in biology schemes as receptors and sensors for carbohydrates, antimicrobial agents and enzyme inhibitors, neutron capture therapy for cancer, transmembrane transport, and bioconjugation and labeling of proteins and cell surface.
關(guān)鍵字： OLED, 吡侖帕奈，氟比洛芬;
河北美星化工有限公司成立于2006年5月，投資8500萬(wàn)元，是一家專業(yè)從事液晶中間體、液晶單體及醫(yī)藥化學(xué)品研發(fā)、生產(chǎn)和銷售的中外合資高科技企業(yè)。
美星化工下轄研發(fā)中心和生產(chǎn)基地。研發(fā)中心位于石家莊市高新區(qū)，面積1000平米，配有先進(jìn)的實(shí)驗(yàn)設(shè)施及檢測(cè)儀器，主要從事新產(chǎn)品研發(fā)與新工藝優(yōu)化。生產(chǎn)基地位于河北省辛集市壘頭工業(yè)區(qū)，占地面積100畝。擁有高溫、高壓、低溫、超低溫等大型反應(yīng)器120多套，并建有萬(wàn)級(jí)純凈車間及萬(wàn)級(jí)精包車間。我們致力于液晶單體、中間體、醫(yī)藥化學(xué)品以及稀有精細(xì)化學(xué)品等的定制合成、委托生產(chǎn)與工藝開發(fā)，可生產(chǎn)從克級(jí)至噸位級(jí)產(chǎn)品，具備年生產(chǎn)液晶產(chǎn)品100噸以上的生產(chǎn)能力。
美星化工質(zhì)量控制中心配備有先進(jìn)的GC、