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Anti-PAF1 Polyclonal Antibody,Anti-PAF1 Polyclonal Antibody
  • Anti-PAF1 Polyclonal Antibody,Anti-PAF1 Polyclonal Antibody

Anti-PAF1 Polyclonal Antibody

價(jià)格 1600.00 960.00
包裝 100ul 50ul
最小起訂量 50ul
發(fā)貨地 北京
更新日期 2024-12-23
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產(chǎn)品詳情

中文名稱:Anti-PAF1 Polyclonal Antibody英文名稱:Anti-PAF1 Polyclonal Antibody
Gene ID: 54623Subcellular Locations: Nucleus
Swiss Prot: Q8N7H5保存: Store at -20°C. Avoid freeze / thaw cycles.
別名: F23149_1;PD2;RNA polymerase II-associated factor 1 homolog產(chǎn)品編號(hào): K107432P
儲(chǔ)存液: Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.純化方法: Affinity purification
蛋白分子量: 55/60kDa交叉反應(yīng): Human Mouse Rat
克隆類型: Polyclonal Antibody免疫原: A synthetic peptide of human PAF1
品牌: Solarbio宿主: Rabbit
稀釋比例: WB 1:8000-12000. IHC 1:25-100.亞型: IgG
應(yīng)用: WB IHC英文名稱: Anti-PAF1 Polyclonal Antibody
2024-12-23 Anti-PAF1 Polyclonal Antibody Anti-PAF1 Polyclonal Antibody 100ul/1600.00RMB;50ul/960.00RMB 1600.00

背景資料

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro.
關(guān)鍵字: Anti-PAF1 Polyclonal Antibody;抗體

公司簡(jiǎn)介

北京索萊寶科技有限公司是一家集研發(fā)、生產(chǎn)、銷售、服務(wù)于一體的高科技生物企業(yè)。技術(shù)推廣;技術(shù)轉(zhuǎn)讓;技術(shù)咨詢;技術(shù)服務(wù);生物試劑技術(shù)開發(fā);銷售生物試劑盒、實(shí)驗(yàn)室專用化學(xué)試劑、實(shí)驗(yàn)室專用設(shè)備、辦公用品、化工產(chǎn)品(不含危險(xiǎn)化學(xué)品)、計(jì)算機(jī)軟件及輔助設(shè)備;貨物進(jìn)出口、技術(shù)進(jìn)出口、代理進(jìn)出口;委托加工生產(chǎn)生物制品、生化制品、化工產(chǎn)品(不含危險(xiǎn)化學(xué)品);生產(chǎn)生物試劑盒;批發(fā)第一類醫(yī)療器械、第二類醫(yī)療器械;批發(fā)第三類醫(yī)療器械。
成立日期 2004-09-22 (21年) 注冊(cè)資本 1000萬元
員工人數(shù) 50-100人 年?duì)I業(yè)額 ¥ 500萬-1000萬
主營行業(yè) 分析化學(xué),生物化工,化學(xué)試劑,醫(yī)藥原料,儀器耗材 經(jīng)營模式 貿(mào)易,工廠,試劑
  • 北京索萊寶科技有限公司
VIP 9年
  • 公司成立:21年
  • 注冊(cè)資本:1000萬元
  • 企業(yè)類型:有限責(zé)任公司
  • 主營產(chǎn)品:tris,甘氨酸,瓊脂粉,潮霉素B,SDS,BSA
  • 公司地址:聯(lián)東U谷景盛南四街85A三層
詢盤

Anti-PAF1 Polyclonal Antibody相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1280
VIP1年
湖北艾普蒂生物工程有限公司
2024-12-23
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