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Anti-GPER1 Polyclonal Antibody,Anti-GPER1 Polyclonal Antibody
  • Anti-GPER1 Polyclonal Antibody,Anti-GPER1 Polyclonal Antibody

Anti-GPER1 Polyclonal Antibody

價格 1600.00 960.00
包裝 100ul 50ul
最小起訂量 50ul
發(fā)貨地 北京
更新日期 2024-12-27
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產(chǎn)品詳情

中文名稱:Anti-GPER1 Polyclonal Antibody英文名稱:Anti-GPER1 Polyclonal Antibody
Gene ID: 2852Public Immunogen Range: A synthetic peptide of human GPER1
Swiss Prot: Q99527保存: Store at -20°C. Avoid freeze / thaw cycles.
別名: CEPR;CMKRL2;DRY12;FEG-1;GPCR-Br;GPER;GPR30;LERGU;LERGU2;LyGPR;mER產(chǎn)品編號: K101555P
儲存液: Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.純化方法: Affinity purification
蛋白分子量: 42kDa交叉反應(yīng): Human Mouse Rat
克隆類型: Polyclonal Antibody免疫原: A synthetic peptide of human GPER1
品牌: solarbio宿主: Rabbit
稀釋比例: WB 1:3000.性狀: 液體
亞型: IgG應(yīng)用: WB
英文名稱: Anti-GPER1 Polyclonal Antibody
2024-12-27 Anti-GPER1 Polyclonal Antibody Anti-GPER1 Polyclonal Antibody 100ul/1600.00RMB;50ul/960.00RMB 1600.00

背景資料

G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.

Subcellular Locations

Basolateral cell membrane Cell junction Cell membrane Cell projection Cytoplasm Cytoplasmic vesicle membrane Early endosome Endoplasmic reticulum membrane Golgi apparatus Golgi apparatus membrane Mitochondrion membrane Multi-pass membrane protein Nucleus Recycling endosome axon cytoskeleton dendrite dendritic spine membrane perinuclear region postsynaptic cell membrane postsynaptic density synapse trans-Golgi network
關(guān)鍵字: Anti-GPER1 Polyclonal Antibody;抗體

公司簡介

北京索萊寶科技有限公司是一家集研發(fā)、生產(chǎn)、銷售、服務(wù)于一體的高科技生物企業(yè)。技術(shù)推廣;技術(shù)轉(zhuǎn)讓;技術(shù)咨詢;技術(shù)服務(wù);生物試劑技術(shù)開發(fā);銷售生物試劑盒、實驗室專用化學(xué)試劑、實驗室專用設(shè)備、辦公用品、化工產(chǎn)品(不含危險化學(xué)品)、計算機(jī)軟件及輔助設(shè)備;貨物進(jìn)出口、技術(shù)進(jìn)出口、代理進(jìn)出口;委托加工生產(chǎn)生物制品、生化制品、化工產(chǎn)品(不含危險化學(xué)品);生產(chǎn)生物試劑盒;批發(fā)第一類醫(yī)療器械、第二類醫(yī)療器械;批發(fā)第三類醫(yī)療器械。
成立日期 2004-09-22 (21年) 注冊資本 1000萬元
員工人數(shù) 50-100人 年營業(yè)額 ¥ 500萬-1000萬
主營行業(yè) 分析化學(xué),生物化工,化學(xué)試劑,醫(yī)藥原料,儀器耗材 經(jīng)營模式 貿(mào)易,工廠,試劑
  • 北京索萊寶科技有限公司
VIP 9年
  • 公司成立:21年
  • 注冊資本:1000萬元
  • 企業(yè)類型:有限責(zé)任公司
  • 主營產(chǎn)品:tris,甘氨酸,瓊脂粉,潮霉素B,SDS,BSA
  • 公司地址:聯(lián)東U谷景盛南四街85A三層
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