產(chǎn)品說明

HIV-1附著抑制劑

該產(chǎn)品包含在以下化合物庫中:

質(zhì)量控制

• 純度 = 98.00%

化學(xué)性質(zhì)

CAS號	864953-39-9	?	?
別名	BMS663068 (Tris);BMS 663068 (Tris)
分子式	C29H37N8O11P	分子量	704.62
溶解性	DMSO	儲存條件	Store at -20°

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實驗操作

細(xì)胞實驗[2]：
細(xì)胞系
溶解方法
反應(yīng)時間
應(yīng)用
動物實驗[3]：
動物模型
劑量
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References:

產(chǎn)品描述

BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection. BMS-663068 is a prodrug for BMS-626529 which binds to the viral envelope glycoprotein gp120 and interferes with attachment of the virus to the cellular CD4 receptor. Administration of BMS-663068 for 8 days with or without ritonavir resulted in substantial declines in plasma HIV-1 RNA levels and was generally well tolerated. Longer-term clinical trials of BMS-663068 as part of combination antiretroviral therapy are warranted.