Species

Gene ID

Accession

Source

Length

MW

Tag

Mouse

66102

Q8BSU2

E. coli

88aa

9.9kDa

－

About this Antibody

Name

Recombinant Murine CXCL16 (Recombinant Murine CXCL16; rMuCXCL16)；Recombinant Mouse CXCL16 ; 重組小鼠CXCL16

Synonyms

CXCL16; chemokine (C-X-C motif) ligand 16; CXC chemokine ligand 16; CXCLG16; Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein; SCYB16; Small-inducible cytokine B16; SRPSOXC-X-C motif chemokine 16; SR-PSOXTransmembrane chemokine CXCL16

Purity

>98% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using murine lymphocytes is in a concentration of 20-1000ng/ml.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in PBS.

Endotoxin

Less than 1EU/μg of rMuCXCL16 as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Chemokines

Background

CXCL16 is a member of the CXC chemokine family. Larger than other chemokines, it is one of the only two transmembrane chemokines in the family and the other is CX3CL1. Mouse CXCL16 has 246a.a. and consists of a 26a.a. residue putative signal peptide, an 88a.a. residue chemokine domain, an 87a.a. residue mucin-like spacer region, a 22a.a. residue transmembrane domain, and a 23a.a. residue cytoplasmic tail. Mouse CXCL16 shares 70% sequence identity with human CXCL16 in chemokine domain. CXCL16 interacts with the chemokine receptor CXCR6, also known as Bonzo. Expression of CXCL16 is induced by the inflammatory cytokines IFN-gamma and TNF-alpha. Functions of CXCL16 include inducing a strong chemotactic response and calcium mobilization. CXCL16 also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis.

Amino Acid Sequence

NQGSVAGSCS CDRTISSGTQ IPQGTLDHIR KYLKAFHRCP FFIRFQLQSK SVCGGSQDQW VRELVDCFER KECGTGHGKS FHHQKHLP

產(chǎn)品編號

產(chǎn)品名稱

包裝

P6762-5μg

Recombinant Murine CXCL16

5μg

P6762-25μg

Recombinant Murine CXCL16

25μg

P6762-100μg

Recombinant Murine CXCL16

100μg

P6762-1mg

Recombinant Murine CXCL16

1mg

-

說明書

1份