Species

Gene ID

Accession

Source

Length

MW

Tag

Mouse

14825

P12850

E. coli

72aa

7.8kDa

－

About this Antibody

Name

Recombinant Murine KC/CXCL1 (Recombinant Murine KC/CXCL1; rMuKC/CXCL1)；Recombinant Mouse KC/CXCL1 ; 重組小鼠角質(zhì)形成細胞衍生趨化因子/CXCL1

Synonyms

CINC-1; GRO alpha; KC; MGSA-alpha

Purity

>97% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration range of 10-100ng/ml.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4.

Endotoxin

Less than 1EU/μg of rMuKC/CXCL1 as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Chemokines

Background

Murine CXCL1, also known as KC, is belonging to the CXC chemokine family. It is encoded by the GRO gene now designated CXCL1. The gene for CXCL1 was initially discovered in mouse fibroblasts by plateletderived growth factor. KC is member of the intercrine alpha (chemokine C-X-C) subfamily of chemokines. It is secreted by human melanoma cells, and also expressed by macrophages, neutrophils and epithelial cells. The functional receptor for CXCL1 has been identified as CXCR2. CXCL1 has chemotactic activity for neutrophils, and plays a role in inflammation and wound healing. Amino acid sequence of murine CXCL1 is approximately 60% identical to the human CXCL1. KC was found to be involved in monocyte arrest on atherosclerotic endothelium and may also play a pathophysiological role in Alzheimer's disease.

Amino Acid Sequence

APIANELRCQ CLQTMAGIHL KNIQSLKVLP SGPHCTQTEV IATLKNGREA CLDPEAPLVQ KIVQKMLKGV PK

產(chǎn)品編號

產(chǎn)品名稱

包裝

P6708-5μg

Recombinant Murine KC/CXCL1

5μg

P6708-20μg

Recombinant Murine KC/CXCL1

20μg

P6708-100μg

Recombinant Murine KC/CXCL1

100μg

P6708-1mg

Recombinant Murine KC/CXCL1

1mg

-

說明書

1份