產(chǎn)品名稱：紫杉醇
拉丁 名：Chinese yew
提取部位：樹皮
提取方法：酒精&酸堿提取
產(chǎn)品外觀：白色或類白色粉末
產(chǎn)品規(guī)格：99.5%
CAS 號：33069-62-4
抗癌類藥品，紫杉醇屬有絲分裂中的微管抑制劑，紫杉醇具有聚合和穩(wěn)定細(xì)胞內(nèi)微管的作用，致使快速分裂的腫瘤細(xì)胞在有絲分裂階段被牢牢固定，使微管不再分開，可阻斷細(xì)胞于細(xì)胞周期之G2與M期，使癌細(xì)胞復(fù)制受阻斷而死亡 。
Production Name:Paclitaxel or Taxol
Original plant:Chinese yew
Specification:99.5%
Test Method:HPLC
Chemical Name:Benzenepropanoic acid,β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2a,4β,4a,β6β,9(R*,βS*),11α,12α,12aα,12bα]]-.
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-Dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]-benz[1,2-b]oxet-5-one 6,12b-diacetate, 12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
Molecular Formula:C47H51NO14
Molecular Weight:853.91
Appearance: White to off-white powder
Solubility:Insoluble in water, soluble in alcoho
CAS No:33069-62-4
Description:Paclitaxel-treated cells have defects in mitotic spindle assembly, chromosome segregation, and cell division. Unlike other tubulin targeted drugs such as colchicine that inhibit microtubule assembly, however, paclitaxel stabilizes the microtubule polymer and protects it from disassembly. The inability of the chromosomes to achieve a metaphase spindle configuration leads to a mitotic block in which there is prolonged activation of the mitotic checkpoint with the subsequent triggering of apoptosis or slippage back into the G1-phase of the cell cycle without cell division.The ability of paclitaxel to inhibit spindle function is generally attributed to its suppression of microtubule dynamics;but recent studies have demonstrated that suppression of dynamics occurs at concentrations lower than those needed to block mitosis. At the higher antimitotic concentrations, paclitaxel appears to act by suppressing microtubule detachment from centrosomes, a process normally activated during mitosis.The binding site for paclitaxel
關(guān)鍵字： Chinese yew；紫衫醇；Paclitaxel or Taxol
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