product name: Cornuside
cas no.:131189-57-6
chemical name;Methyl (2R,3S,4R)-3-ethenyl-4-[2-(3,4,5-trihydroxybenzoyl)oxyethyl]-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4-dihydro-2H-pyran-5-carboxylate
molecular formula: C24H30O14
molecular weight: 542.49
solubility: soluble in Pyridine, Methanol
appearance: powder
purity by hplc: >98%
biological activity:Cornuside has immunomodulatory activity; Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells; Cornuside can treat myocardial I/R and protect the liver from CCl?-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses; Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells; Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties.
關(guān)鍵字： 山茱萸新苷;山茱萸裂甙;Cornuside;Cornuside I
上海水正生物醫(yī)藥科技有限公司（Arethusa-水正生物）是一家專業(yè)從事高純度天然藥物單體的研發(fā)及銷售的科技型企業(yè)。主營業(yè)務(wù)包括中藥對照品、植物標(biāo)準(zhǔn)品、天然藥物活性單體、藥物雜質(zhì)分離純化、工藝開發(fā)研究及技術(shù)外包服務(wù)。
水正生物致力于構(gòu)建全球最有影響力的“大規(guī)模、高質(zhì)量天然產(chǎn)物庫”，為全球創(chuàng)新藥物研發(fā)機構(gòu)提供豐富的物質(zhì)基礎(chǔ)，為全產(chǎn)業(yè)發(fā)展搭建基礎(chǔ)性支撐平臺。該庫現(xiàn)已擁有3,000余種結(jié)構(gòu)類型多樣的天然化合物，幾乎涵蓋絕大部分已知的天然產(chǎn)物結(jié)構(gòu)類型，其中超過60%的產(chǎn)品無法從商業(yè)渠道獲得或現(xiàn)貨供應(yīng)商極少，它們源于650多種藥用植物或真菌（包括部分中藥），并且品種仍在持續(xù)豐富。