中文名稱：環(huán)巴胺;環(huán)杷明;去氧芥芬胺
英文名稱：Cyclopamine;11-deoxojervine;(3b,23b)-17,23-Epoxy-11-deoxoveratraman-3-ol
CAS：4449-51-8
純度：98% HPLC
Product Name: Cyclopamine(11-Deoxyjervine)
Botanical Source: Veratrum californicim (plant extract)
CAS No.: 4449-51-8
Synonyms:11-Deoxojervine; (3b,23b)-17,23-Epoxy-11-deoxoveratraman-3-ol
Chemical Name: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,
11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol
Molecular Formula:C27H41NO2
Molecular Weight 411.62
Appearance: White to off-white powder
Solubility: Soluble in 100% ethanol (20mg/ml), DMSO (4mg/ml), dimethyl formamide (10mg/ml), methanol (7mg/ml). Insoluble in water.
Purity: >98% (HPLC)
Description:
Cyclopamine is a natural steroidal jerveratrum alkaloide. Cyclopamine is named after its ability to cause cyclopia(holoprosencephaly) in unborn sheep.
Cyclopamine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling. It specifically inhibits the hedgehog (Hh) pathway by interaction with the Hh signaling protein smoothened. Cyclopamine blocks the oncogenic effects of mutations of Ptch in fibroblasts and inhibits the growth of cells lacking Ptch function. It arrested cell cycle at G0/G1 and induced apoptosis in several small-cell lung cancer cell lines at 5 µM. Cyclopamine also induces expression of the transcription factor pdx-1, which stimulates insulin secretion in differentiation protocols for mouse embryonic stem cells.
關(guān)鍵字： Cyclopamine;11-deoxojervine;環(huán)巴胺;環(huán)杷明;去氧芥芬胺;4449-51-8
上海水正生物醫(yī)藥科技有限公司（Arethusa-水正生物）是一家專業(yè)從事高純度天然藥物單體的研發(fā)及銷售的科技型企業(yè)。主營業(yè)務(wù)包括中藥對照品、植物標(biāo)準(zhǔn)品、天然藥物活性單體、藥物雜質(zhì)分離純化、工藝開發(fā)研究及技術(shù)外包服務(wù)。
水正生物致力于構(gòu)建全球最有影響力的“大規(guī)模、高質(zhì)量天然產(chǎn)物庫”，為全球創(chuàng)新藥物研發(fā)機(jī)構(gòu)提供豐富的物質(zhì)基礎(chǔ)，為全產(chǎn)業(yè)發(fā)展搭建基礎(chǔ)性支撐平臺。該庫現(xiàn)已擁有3,000余種結(jié)構(gòu)類型多樣的天然化合物，幾乎涵蓋絕大部分已知的天然產(chǎn)物結(jié)構(gòu)類型，其中超過60%的產(chǎn)品無法從商業(yè)渠道獲得或現(xiàn)貨供應(yīng)商極少，它們源于650多種藥用植物或真菌（包括部分中藥），并且品種仍在持續(xù)豐富。