英文名稱Rabbit Anti-DRD2 antibody
中文名稱多巴胺受體D2抗體
別 名DRD2_HUMAN; D(2) dopamine receptor; Dopamine D2 receptor; dopamine receptor D2; D2R; D2DR;
研究領(lǐng)域腫瘤 免疫學(xué) 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞膜受體
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,Mouse,Rat (predicted: Rabbit,Sheep,Cow,Dog,Horse)
產(chǎn)品應(yīng)用WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量51kDa
細(xì)胞定位細(xì)胞膜
性 狀Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human DRD2: 1-100/443 <Extracellular>
亞 型IgG
純化方法affinity purified by Protein A
緩 沖 液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
產(chǎn)品介紹This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
Function:
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Subcellular Location:
Cell membrane.
DISEASE:
Defects in DRD2 are associated with dystonia type 11 (DYT11) [MIM:159900]; also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
SWISS:
P14416
Gene ID:
1813
關(guān)鍵字： 多巴胺受體D2抗體;Dopamine D2 Receptor;多巴胺受體D2抗體;雅吉抗體;一抗;
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