PF06463922    

CAS NO.    1454846-35-5    
英文品名     PF-06463922
中文品名     PF-06463922
分子式    C21H19FN6O2
分子量    406.15
規(guī)格/純度    98%
供應(yīng)能力    can supply g scale
別名     PF 06463922;PF06463922
產(chǎn)品簡述     PF-06463922 is a novel, orally available, CNS-penetrant, ATP-competitive inhibitor of ALK/ROS1 with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.
詳細說明    PF-06463922 demonstrates significant cell activity against ALK and a large set of ALK clinical mutations with IC50 ranging from 0.2 nM-77 nM. PF-06463922 exhibited subnanomolar cellular potency against oncogenic ROS1 fusions and inhibited the crizotinib-refractory ROS1(G2032R) mutation and the ROS1(G2026M) gatekeeper mutation. Compared with crizotinib and the second-generation ALK/ROS1 inhibitors ceritinib and alectinib, PF-06463922 showed significantly improved inhibitory activity against ROS1 kinase. in vivo: PF-06463922 showed marked antitumor activity in tumor models expressing FIG-ROS1, CD74-ROS1, and the CD74-ROS1(G2032R) mutation. Furthermore, PF-06463922 demonstrated antitumor activity in a genetically engineered mouse model of FIG-ROS1 glioblastoma.

湖北帝柏化工有限公司總部成立于09年，位于湖北省長江中游兩岸，中國歷史文化名城之一的“荊州”。帝柏化工先后創(chuàng)立荊州區(qū)精細化工原料廠、孝感云夢醫(yī)藥原料廠兩大生產(chǎn)型單位。是省重點扶持集研發(fā)、生產(chǎn)、銷售一體的高新技術(shù)產(chǎn)業(yè)單位，被譽為湖北化工行業(yè)“企業(yè)之星”。