DR6產(chǎn)品信息

英文名稱：Tumor necrosis factor receptor superfamily member 21

中文名稱：腫瘤壞死因子受體超家族成員21

靶點(diǎn)別稱：TNFRSF21,DR6,CD358,BM-018

物種：Human

標(biāo)簽：Fc Tag

屬性：Protein

標(biāo)記：Unconjugated

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human DR6, Fc Tag (TN1-H5252) is expressed from human 293 cells (HEK293). It contains AA Gln 42 - Leu 350 (Accession # AAH17730).

Predicted N-terminus: Gln 42

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 60.2 kDa. The protein migrates as 80-95kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

腫瘤壞死因子受體超家族成員21（TNFRSF21）也稱為死亡受體6（DR6），是TNF受體超家族的成員。TNFRSF21包含一個(gè)死亡結(jié)構(gòu)域和四個(gè)TNFR-Cys重復(fù)序列。TNFRSF21/DR6已被證明可以激活NF-κB和MAPK8/JNK，并誘導(dǎo)細(xì)胞凋亡。通過其死亡結(jié)構(gòu)域，該受體與TRADD蛋白相互作用，TRADD蛋白被認(rèn)為是介導(dǎo)TNF受體信號(hào)轉(zhuǎn)導(dǎo)的接頭。